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Merck

00942

N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide

for GC derivatization, LiChropur™, ≥95.0% (GC), with 1% tert-Butyldimethylchlorosilane

Synonym(s):

N-Methyl-N-tert-butyldimethylsilyltrifluoroacetamide, MTBSTFA + 1% TBDMSCl, Silylating mixture VI

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About This Item

Empirical Formula (Hill Notation):
C9H18F3NOSi
CAS Number:
77377-52-7
Molecular Weight:
241.33
UNSPSC Code:
41116105
PubChem Substance ID:
329747171
NACRES:
NA.22
Beilstein/REAXYS Number:
3606546
MDL number:
MFCD00009671

Product Name

N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide with 1% tert-Butyldimethylchlorosilane, LiChropur™, ≥95.0% (GC)

SMILES string

CN(C(=O)C(F)(F)F)[Si](C)(C)C(C)(C)C

InChI key

QRKUHYFDBWGLHJ-UHFFFAOYSA-N

InChI

1S/C9H18F3NOSi/c1-8(2,3)15(5,6)13(4)7(14)9(10,11)12/h1-6H3

grade

derivatization grade ((GC derivatization))

assay

≥95.0% (GC)

form

liquid

quality

LiChropur™

reaction suitability

reagent type: derivatization reagent
reaction type: Silylations

technique(s)

gas chromatography (GC): suitable

impurities

0.5-1.5% tert-butyldimethylchlorosilane

storage temp.

2-8°C

Quality Level

100

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Application

MTBSTFA + 1% TBDMSCl can be used as a derivatizing reagentin the analysis of:
  • Organic acid profile in human serum by gaschromatography/mass spectrometry (GC/MS).
  • Nerveagents and their breakdown products by GC–MS-MS method.

General description

N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamidewith 1% tert-Butyldimethylchlorosilane (TBDMS) is a derivatizing reagentcommonly used in gas chromatography (GC) and gas chromatography-massspectrometry (GC-MS).

Other Notes

Discover LiChropur™ reagents ideal for HPLC or LC-MS analysis

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2

Storage Class

3 - Flammable liquids

wgk

WGK 3

flash_point_f

113.0 °F - closed cup

flash_point_c

45 °C - closed cup

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN2332
BCCL3067
BCCJ4835
BCCG8048
BCCF1600

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Gas chromatography/mass spectrometry analysis of organic acid profiles in human serum: A protocol of direct ultrasound-assisted derivatization
Zhang MJ, et al.
Rapid Communications in Mass Spectrometry, 35(17), e9149-e9149 (2021)
Mass spectrometry of anabolic steroids as their tert-butyldimethylsilyl ether derivatives.
Steffenrud, S.
Rapid Communications in Mass Spectrometry, 10, 1698-1702 (1996)
The Application of a single-column GC--MS-MS method for the rapid analysis of chemical warfare agents and breakdown products
Young SA, et al.},
Journal of Analytical Toxicology, 43(3), 179-187 (2019)
Xue Shi et al.
Journal of proteome research, 14(2), 1174-1182 (2015-01-17)
The interactions among the gut, liver, and immune system play an important role in liver disease. Probiotics have been used for the treatment and prevention of many pathological conditions, including liver diseases. Comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry (GC×GC-TOF
Tsubasa Nakajima et al.
Plant & cell physiology, 55(9), 1605-1612 (2014-06-28)
Cyanobacteria have flexible metabolic capability that enables them to adapt to various environments. To investigate their underlying metabolic regulation mechanisms, we performed an integrated analysis of metabolic flux using transcriptomic and metabolomic data of a cyanobacterium Synechocystis sp. PCC 6803
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