15209
N,O-Bis(trimethylsilyl)trifluoroacetamide with trimethylchlorosilane
derivatization grade (GC derivatization), LiChropur™, contains 10% TMCS, 98% (excluding TMCS)
Synonym(s):
BSTFA + TMCS
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About This Item
Linear Formula:
CF3C[=NSi(CH3)3]OSi(CH3)3
CAS Number:
Molecular Weight:
257.40
UNSPSC Code:
41116105
NACRES:
NA.22
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
2050024
Product Name
N,O-Bis(trimethylsilyl)trifluoroacetamide with trimethylchlorosilane, derivatization grade (GC derivatization), LiChropur™, contains 10% TMCS, 98% (excluding TMCS)
InChI
1S/C8H18F3NOSi2/c1-14(2,3)12-7(8(9,10)11)13-15(4,5)6/h1-6H3/b12-7+
SMILES string
C[Si](C)(C)O\C(=N\[Si](C)(C)C)C(F)(F)F
InChI key
XCOBLONWWXQEBS-KPKJPENVSA-N
grade
derivatization grade (GC derivatization)
assay
≥97.5% (excluding TMCS, GC)
98% (excluding TMCS)
form
liquid
quality
LiChropur™
reaction suitability
reagent type: derivatization reagent
reaction type: Silylations
technique(s)
gas chromatography (GC): suitable
impurities
9.0-11.0% TMCS
refractive index
n20/D 1.384 (lit.)
bp
45-50 °C/14 mmHg (lit.)
density
0.97 g/mL (lit.)
Quality Level
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Application
- Determination of Δ(9)-tetrahydrocannabinol, 11-nor-carboxy-Δ(9)-tetrahydrocannabinol and cannabidiol in human plasma and urine after a commercial cannabidiol oil product intake.: This study uses N,O-Bis(trimethylsilyl)trifluoroacetamide with trimethylchlorosilane for derivatization to enhance the sensitivity and accuracy of cannabinoid detection in biological samples. This method is vital for forensic toxicology and clinical research, providing reliable data for cannabinoid analysis (Papoutsis et al., 2024).
- The impact of lipid degradation on fingerprint quality on fired firearm cartridges.: This research employs N,O-Bis(trimethylsilyl)trifluoroacetamide with trimethylchlorosilane to study lipid degradation and its effect on fingerprint quality on firearm cartridges. The findings are crucial for forensic science, particularly in improving methods for preserving and analyzing fingerprint evidence (Goulart et al., 2023).
- Contaminants of emerging concern: Silylation procedures, evaluation of the stability of silyl derivatives and associated measurement uncertainty.: This paper evaluates the use of N,O-Bis(trimethylsilyl)trifluoroacetamide with trimethylchlorosilane in silylation procedures for environmental analysis. The study assesses the stability and measurement uncertainty of silyl derivatives, which is crucial for accurate monitoring of environmental contaminants (Ljoncheva et al., 2023).
- Screening of Organic Acidurias by Gas Chromatography-Mass Spectrometry (GC-MS).: This research utilizes N,O-Bis(trimethylsilyl)trifluoroacetamide with trimethylchlorosilane in the derivatization process for screening organic acidurias. This method is significant for clinical diagnostics, providing a reliable approach for detecting metabolic disorders (Scott et al., 2022).
- A sensitive, robust method for determining natural and synthetic hormones in surface and wastewaters by continuous solid-phase extraction-gas chromatography-mass spectrometry.: The study presents a method using N,O-Bis(trimethylsilyl)trifluoroacetamide with trimethylchlorosilane for the detection of hormones in environmental samples. This robust method is essential for monitoring water quality and detecting endocrine-disrupting compounds (Chafi and Ballesteros, 2022).
General description
N,O-Bis(trimethylsilyl)trifluoroacetamide with trimethylchlorosilane has found application to be used in gas chromatography (GC) and mass-spectrometry (MS). It can also be used in HPLC- electrochemical detection assay of 8-oxo-deoxyguanosine and?8-oxo-guanine.
Other Notes
The position of the silyl groups has not been unequivocally established. It has been referred to as both N,N and N,O.
Legal Information
LiChropur is a trademark of Merck KGaA, Darmstadt, Germany
hcodes
signalword
Danger
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1A
Storage Class
3 - Flammable liquids
wgk
WGK 3
flash_point_f
15.8 °F - closed cup
flash_point_c
-9 °C - closed cup
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
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