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Merck

81242

Poly(ethylene glycol)

greener alternative

tested according to Ph. Eur., 4,000

Synonym(s):

Macrogol 4,000, Polyethylene glycol, PEG

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About This Item

Linear Formula:
H(OCH2CH2)nOH
CAS Number:
25322-68-3
NACRES:
NA.21
PubChem Substance ID:
24887707
UNSPSC Code:
12352104
MDL number:
MFCD00081839

Product Name

Poly(ethylene glycol), tested according to Ph. Eur., 4,000

InChI

1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2

SMILES string

C(CO)O

InChI key

LYCAIKOWRPUZTN-UHFFFAOYSA-N

agency

tested according to Ph. Eur.

form

solid

mol wt

3500-4500

greener alternative product characteristics

Safer Solvents and Auxiliaries
Learn more about the Principles of Green Chemistry.

sustainability

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application(s)

pharmaceutical (small molecule)

greener alternative category

Aligned

Quality Level

200

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Application

Poly(ethylene glycol) may be used in the following studies:
  • For the modification of proteins to form the conjugates having increased circulating life and reduced immunogenicity and antigenicity.
  • Preparation of hydrogels useful for the diffusion controlled delivery of proteins.
  • Preparation of poly(ethylene glycol) dimethacrylate (PEGDM).

General description

Poly(ethylene glycol) (PEG) is a non-toxic water-soluble polymer. PEG term is used for the polymer chains with molecular weights below 20 000, while poly(ethylene oxide) (PEO) refers to the higher molecular weight polymers. PEG has various biomedical applications. It forms complexes with α-cyclodextrins. Engineering of PEG hydrogel particles by mesoporous silica (MS) templating method has been reported.
We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Green Chemistry. Polyethylene glycol (PEG) is an eco-friendly, biodegradable polymer widely used in pharmaceuticals and cosmetics. Its non-toxic nature and versatility make it a sustainable choice, derived from renewable resources, contributing to greener product formulations. Click here for more information.

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN0940
BCCL8070
BCCL0808
BCCK1009
BCCH5360

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The clinical efficacy of poly (ethylene glycol)-modified proteins.
Fuertges F and Abuchowski A.
Journal of Controlled Release : Official Journal of the Controlled Release Society, 11(1), 139-148 (1990)
Stephanie J Bryant et al.
Annals of biomedical engineering, 32(3), 407-417 (2004-04-21)
In approaches to tissue engineer articular cartilage, an important consideration for in situ forming cell carriers is the impact of mechanical loading on the cell composite structure and function. Photopolymerized hydrogel scaffolds based on poly(ethylene glycol) (PEG) may be synthesized
Complex formation between poly (ethylene glycol) and α-cyclodextrin.
Harada A and Kamachi M.
Macromolecules, 23(10), 2821-2823 (1990)
N A Peppas et al.
Journal of controlled release : official journal of the Controlled Release Society, 62(1-2), 81-87 (1999-10-16)
The use of hydrogels as carriers for protein delivery has been a subject of significant recent research. In our recent work, we have shown that diffusion controlled delivery of proteins from hydrogels containing poly(ethylene glycol) (PEG) can be possible and
I L Konorova et al.
Patologicheskaia fiziologiia i eksperimental'naia terapiia, (4)(4), 7-9 (1991-07-01)
The search for antiaggregatory compounds is undertaken, as a rule, under in vitro conditions which do not reflect the dynamics of the real process. The present work deals with study of the peculiarities of the development of the collagen induced
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