91928

2′,4′,6′-Trihydroxyacetophenone monohydrate

Name: 2′,4′,6′-Trihydroxyacetophenone monohydrate
Brand: SIAL

suitable for matrix substance for MALDI-MS, ≥99.5%

Synonym(s):

2-Acetylphloroglucinol, THAP

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All Photos(2)

About This Item

Linear Formula:

(HO)₃C₆H₂COCH₃·H₂O

CAS Number:

249278-28-2

Molecular Weight:

186.16

UNSPSC Code:

41115716

NACRES:

NA.21

PubChem Substance ID:

329770099

MDL number:

MFCD00149091

Beilstein/REAXYS Number:

9288656

Product Name

2′,4′,6′-Trihydroxyacetophenone monohydrate, suitable for matrix substance for MALDI-MS, ≥99.5%

InChI

1S/C8H8O4.H2O/c1-4(9)8-6(11)2-5(10)3-7(8)12;/h2-3,10-12H,1H3;1H2

SMILES string

O.CC(=O)c1c(O)cc(O)cc1O

InChI key

GDSIBPPJKSBCMF-UHFFFAOYSA-N

assay

≥99.5% (HPLC)
≥99.5%

form

solid

analyte chemical class(es)

glycans, oligonucleotides, peptides, proteins

technique(s)

MALDI-MS: suitable

color

light yellow

mp

218-222 °C
219-221 °C (lit.)

cation traces

Ca: ≤200 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤50 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Na: ≤50 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Zn: ≤5 mg/kg

suitability

in accordance for UV test
suitable for matrix substance for MALDI-MS

Quality Level

100

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Analytical Reagents

Chromatography & Spectroscopy Reagents

Application

2′,4′,6′-Trihydroxyacetophenone monohydrate has been used as a matrix for oligosaccharide and glycopeptide analysis using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI/TOF).

Used in MALDI analysis of acidic glycans and glycopeptides in negative ion mode. Lower limit of detection than 6-aza-2-thiothimidine.

General description

MALDI-MS analyzes require highest purity matrices and reagents, as organic or trace metal contamination causes adverse effects during crystallization, ionization or measurement. Therefore, our portfolio of MALDI matrices and reagents such as 2′,4′,6′-Trihydroxyacetophenone monohydrate are designed to fulfill the demanding requirements of today′s challenging applications.

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Analysis of acidic oligosaccharides and glycopeptides by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.

Papac, Damon I., Anissa Wong, and Andrew JS Jones.

Analytical Chemistry, 68.18, 3215-3223 (1996)

Analysis of acidic oligosaccharides and glycopeptides by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.

D I Papac et al.

Analytical chemistry, 68(18), 3215-3223 (1996-09-15)

2,5-Dihydroxybenzoic acid (DHB) is the most commonly used matrix for matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI/TOF) of oligosaccharides. Because acidic, sialylated oligosaccharides are detected at only the low picomole level with DHB, alternative matrices were screened to identify a

Matrix-assisted laser desorption ionization time-of-flight mass spectrometry: a powerful tool for the mass and sequence analysis of natural and modified oligonucleotides.

U Pieles et al.

Nucleic acids research, 21(14), 3191-3196 (1993-07-11)

We report the analysis and characterization of natural and modified oligonucleotides by matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS). The present technology was highly improved for this class of compounds by using a new matrix, 2,4,6-trihydroxy acetophenone, together

Analysis of anthocyanins in red wine and fruit juice using MALDI-MS.

J Wang et al.

Journal of agricultural and food chemistry, 47(5), 2009-2015 (1999-12-20)

Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) is a powerful new technique that will have a great impact on food analysis. This study is the first to demonstrate the applicability of MALDI-MS to perform both qualitative and quantitative analyses of anthocyanins

A novel binary matrix consisting of graphene oxide and caffeic acid for the analysis of scutellarin and its metabolites in mouse kidney by MALDI imaging.

Tao Wang et al.

The Analyst, 146(1), 289-295 (2020-11-04)

Although the in vivo metabolic pathways of scutellarin, a traditional Chinese medicine, have been investigated via different liquid chromatography techniques, studies on the distribution and location of scutellarin within organ tissue sections have not been reported. Matrix-assisted laser desorption/ionization mass

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