A3658
N8-Acetylspermidine dihydrochloride
analytical standard
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About This Item
Empirical Formula (Hill Notation):
C9H21N3O · 2HCl
CAS Number:
Molecular Weight:
260.20
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
3698131
InChI
1S/C9H21N3O.2ClH/c1-9(13)12-8-3-2-6-11-7-4-5-10;;/h11H,2-8,10H2,1H3,(H,12,13);2*1H
SMILES string
Cl.Cl.CC(=O)NCCCCNCCCN
InChI key
BWGUIRARVGYOIR-UHFFFAOYSA-N
grade
analytical standard
technique(s)
mass spectrometry (MS): suitable
format
neat
storage temp.
2-8°C
Quality Level
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signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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M Lurdes et al.
Acta chemica Scandinavica (Copenhagen, Denmark : 1989), 43(10), 990-994 (1989-11-01)
The synthesis of all three monoacetylated spermidines is reported. N4-Acetylspermidine was obtained in four steps from spermidine via the triacetylated intermediate by selective deacetylation after exhaustive t-butoxycarbonylation as well as directly from a previously described protected precursor. N1-Acetylspermidine and N8-acetylspermidine
T S Weiss et al.
Cell proliferation, 35(5), 257-267 (2002-09-25)
Extracellular matrices, like collagen layers, play an important role in preventing dedifferentiation of hepatocytes in long-term culture experiments. It has also been shown that polyamines are crucial for cell growth and liver differentiation - regeneration. Primary cultured hepatocytes with their
J E Morgan et al.
Archives of biochemistry and biophysics, 246(1), 225-232 (1986-04-01)
The effect of Mg2+, putrescine, diaminopropane, N1-acetylspermidine, N8-acetylspermidine, spermidine, and spermine on the thermal denaturation of calf thymus DNA was investigated. As in a previous study with magnesium [W.F. Dove and N. Davidson, (1962) J. Mol. Biol. 5, 467-478], these
A Sessa et al.
Cancer letters, 76(2-3), 121-125 (1994-01-30)
N-ethyl-N-nitrosourea-induced rat gliomas showed a stimulation of cytosolic spermidine N-acetyltransferase activity compared with normal brain, with an increased formation of N1 and N8-acetylspermidine, suggesting the activation of two enzymes acetylating the polyamine in N1 and N8 position, respectively. The enhancement
A G Halline et al.
Cancer research, 49(17), 4721-4723 (1989-09-01)
1,2-Dimethylhydrazine (DMH) is a potent procarcinogen with selectivity for the colon. Recently, it has been demonstrated that levels of N1-acetylspermidine were elevated 2-3-fold in colonic tumors induced by this agent compared to control tissues. To determine whether alterations in the
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