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Merck

PHR1045

Diethylene glycol

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

DEG, 2,2′-Oxydiethanol, 2-Hydroxyethyl ether, Bis(2-hydroxyethyl) ether, Diglycol

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About This Item

Linear Formula:
(HOCH2CH2)2O
CAS Number:
111-46-6
Molecular Weight:
106.12
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823075
EC Number:
203-872-2
Beilstein/REAXYS Number:
969209
MDL number:
MFCD00002882

Key Documents

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InChI

1S/C4H10O3/c5-1-3-7-4-2-6/h5-6H,1-4H2

InChI key

MTHSVFCYNBDYFN-UHFFFAOYSA-N

SMILES string

OCCOCCO

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. Y0000217, traceable to USP 1193265

vapor density

2.14 (vs air)

vapor pressure

0.01 mmHg ( 20 °C)

API family

diethylene glycol

CofA

current certificate can be downloaded

autoignition temp.

442 °F

expl. lim.

2-12.3 %

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

refractive index

n20/D 1.447 (lit.)

bp

245 °C (lit.)

mp

−10 °C (lit.)

density

1.118 g/mL at 25 °C (lit.)

application(s)

cleaning products
cosmetics
food and beverages
personal care
pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Diethylene glycol is a a four carbon dimer of ethylene glycol and finds applications as antifreeze, solvent, humectant, hydraulic fluid and brake fluid. It is a potential neuro- and nephrotoxin for humans. It may also be utilized in moisturizers, lubricants, emulsification agents, additives and solvents.

Application

Diethylene glycol may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by high performance liquid chromatography (HPLC).
Diethylene glycol may be used as a standard in the determination of diethylene glycol present in serum samples using gas chromatography (GC). It may also be used as a reference standard in validating the composition of diethylene glycol in propolis syrup consumed by intoxicated victims using nuclear magnetic resonance studies (NMR) and gas chromatography coupled with flame ionization detector (GC-FID).
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC0277 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

10 - Combustible liquids

flash_point_f

280.4 °F - closed cup

flash_point_c

138 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Identification and quantification of diethylene glycol in pharmaceuticals implicated in poisoning epidemics: an historical laboratory perspective
Bar.BD, et al.
Journal of Analytical Toxicology, 31(6), 295-303 (2007)
Clinical parameters, postmortem analysis and estimation of lethal dose in victims of a massive intoxication with diethylene glycol
Ferrari.AL and Giannuzzi L
Forensic Science International, 153, 45-51 (2005)
Tao Zhou et al.
Journal of separation science, 30(16), 2620-2627 (2007-09-21)
A simple and reliable HPLC method was developed for the simultaneous quantitative analysis of diethylene glycol (DEG) and propylene glycol (PG) in pharmaceutical products by precolumn derivatization. The derivatization reagent p-toluenesulfonyl isocyanate (TSIC, 10 microL, 20% in ACN v/v) was
Gas-chromatographic determination of ethylene glycol in serum
Porter H.W and Auansakul aA
Clinical Chemistry, 28, 75-78 (1982)
Ze-Jian Wang et al.
Journal of photochemistry and photobiology. B, Biology, 115, 16-24 (2012-07-17)
Photodynamic therapy (PDT) has recently been proposed as a possible indication in the conservative treatment of hereditary retinoblastoma. In order to create photosensitizers with enhanced targeting ability toward retinoblastoma cells, meso-tetraphenylporphyrins bearing one glycodendrimeric moiety have been synthesized. The binding
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