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Merck

PHR1118

Propyl gallate

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

PG, 3,4,5-Trihydroxybenzoic acid propyl ester

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About This Item

Linear Formula:
3,4,5-(HO)3C6H2CO2CH2CH2CH3
CAS Number:
121-79-9
Molecular Weight:
212.20
NACRES:
NA.24
E Number:
E310
PubChem Substance ID:
329823139
UNSPSC Code:
41116107
EC Number:
204-498-2
MDL number:
MFCD00002196
Beilstein/REAXYS Number:
1877976

Key Documents

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Product Name

Propyl gallate, Pharmaceutical Secondary Standard; Certified Reference Material

format

neat

InChI

1S/C10H12O5/c1-2-3-15-10(14)6-4-7(11)9(13)8(12)5-6/h4-5,11-13H,2-3H2,1H3

InChI key

ZTHYODDOHIVTJV-UHFFFAOYSA-N

SMILES string

CCCOC(=O)c1cc(O)c(O)c(O)c1

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to Ph. Eur. P3640000
traceable to USP 1576800

API family

propyl gallate

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

146-149 °C (lit.)

application(s)

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care
pharmaceutical (small molecule)

storage temp.

2-30°C

Quality Level

300

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Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Application

Propyl gallate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and fatty liquids by chromatography and spectrophotometry.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Propyl gallate is a synthetic phenolic antioxidant (SPA) utilized in food additives to inhibit or regulate the lipid oxidation. SPAs are cost-effective, largely available and highly efficient in comparison to their natural counterparts.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA8981 in the slot below. This is an example certificate only and may not be the lot that you receive.

Preparation Note

Prepare a 0.1M solution in glycerol:PBS (9:1)

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Sens. 1

Storage Class

13 - Non Combustible Solids

wgk

WGK 2

flash_point_f

368.6 °F - closed cup

flash_point_c

187 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Method validation and measurement uncertainty for the simultaneous determination of synthetic phenolic antioxidants in edible oils commonly consumed in Korea
Kim JM, et al.
Food Chemistry, 213(6), 19-25 (2016)
Determination of some antioxidants by derivative spectrophotometric method and high-performance liquid chromatography
Ivanovic D, et al.
Analytical Letters, 23(6), 1123-1137 (1990)
Detection and quantification of low-molecular-weight aldehydes in pharmaceutical excipients by headspace gas chromatography
Li Z, et al.
Journal of Chromatography A, 1104(1-2), 1-10 (2006)
Paola Colindres et al.
Journal of the science of food and agriculture, 91(5), 963-968 (2011-01-22)
The effect of selected antioxidants (grape seed extract (GS), oleoresin rosemary (OR), water-soluble oregano extract (WO), propyl gallate (PG), butylated hydroxyanisole (BHA)), butylated hydroxytoluene (BHT)) on sensory, color and oxidative stability of cooked, frozen, reheated ground beef patties was evaluated.
Ching-Hsein Chen et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 49(2), 494-501 (2010-11-30)
Propyl gallate (PG) is a synthetic antioxidant that has been used in processed food and medicinal preparations. The anti-cancer effect of PG in leukemia is unclear. In the present study, we demonstrate that PG reduced cell viability in THP-1, Jurkat
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