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Merck

PHR1277

Nitrilotriacetic acid

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Nitrilotriacetic acid, N,N-Bis(carboxymethyl)glycine, NTA, Tris(carboxymethyl)amine

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About This Item

Linear Formula:
N(CH2COOH)3
CAS Number:
139-13-9
Molecular Weight:
191.14
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823273
EC Number:
205-355-7
Beilstein/REAXYS Number:
1710776
MDL number:
MFCD00004287

Product Name

Nitrilotriacetic acid, Pharmaceutical Secondary Standard; Certified Reference Material

InChI key

MGFYIUFZLHCRTH-UHFFFAOYSA-N

InChI

1S/C6H9NO6/c8-4(9)1-7(2-5(10)11)3-6(12)13/h1-3H2,(H,8,9)(H,10,11)(H,12,13)

SMILES string

OC(=O)CN(CC(O)=O)CC(O)=O

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to USP 1463950

API family

edta

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

245 °C (dec.) (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Quality Level

300

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Analysis Note

These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.

Application

An excellent chelating agent.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Nitrilotriacetic acid can be used as an internal standard in the determination of nitrilotriacetic acid in water.

General description

Nitrilotriacetic acid (NTA) is a polyaminopolycarboxylic acid, widely used as a synthetic chelating agent. It forms stable and water-soluble chelates with different metals. It is used as a detergent builder to soften water and for masking metal ions in various industrial processes.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC3702 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

212.0 °F - closed cup

flash_point_c

100 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Determination of nitrilotriacetic acid and ethylenediaminetetraacetic acid in environmental samples as their methyl ester derivatives by gas chromatography-mass spectrometry
Nishikawa Y and Okumura T
Journal of Chromatography A, 690(1), 109-118 (1995)
Quantitative gas chromatographic determination of nitrilotriacetic acid in the presence of other carboxylic acids
Larson RA, et al.
Journal of Chromatography A, 111(1), 43-49 (1975)
Determination of the solubility products of nitrilotriacetic acid, ethylenediaminetetraacetic acid and diethylenetriaminepentaacetic acid.
Karhu J, et al.
Analytica Chimica Acta, 380(1), 105-111 (1999)
The determination of part-per-billion levels of citric and nitrilotriacetic acids in tap water and sewage effluents
Aue WA, et al.
Journal of Chromatography A, 72(2), 259-267 (1972)
R L Anderson et al.
Critical reviews in toxicology, 15(1), 1-102 (1985-01-01)
This article provides a review of available information on the chemistry, environmental toxicology, and mammalian toxicology of nitrilotriacetic acid (NTA). The ability of NTA to chelate metal ions such as Mg++ and Ca++ into water soluble complexes makes NTA useful
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