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78973

Poloxamer 188, micronized

Synonym(s):

Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol), Lμtrol micro 68

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About This Item

CAS Number:
9003-11-6
UNSPSC Code:
12161900
NACRES:
NA.25
MDL number:
MFCD00082049
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form

powder

Quality Level

100

mol wt

~7680-9510 g/mol

composition

oxyethylene content, 79.9-83.7%

technique(s)

DNA extraction: suitable, DNA purification: suitable, NMR: suitable, RNA extraction: suitable, RNA purification: suitable

impurities

organic volatile impurities, complies (meets USP requirements), ≤0.4% total ash, ≤0.75% water, ≤1 ppm ethylene oxide, ≤20 ppm heavy metals, ≤5 ppm 1,4-dioxane, ≤5 ppm propylene oxide, 50-125 ppm butylhydroxytoluene

color

APHA: ≤100

particle size distribution

, coeff var ≤10% (residue, No. 140 USS), , coeff var ≤50% (residue, No 270 USS)

pH

5.0-7.5 (2.5% in H2O)

suitability

complies for Infrared spectrum

SMILES string

O2C(C2)C.O1CC1

InChI

1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2

InChI key

RVGRUAULSDPKGF-UHFFFAOYSA-N

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Other Notes

The Poloxamer 188 grades are poloxamers from the extensive line of Pluronic® block copolymers.
average molecular weight/mass 7680-9510 g/mol

Legal Information

Pluronic is a registered trademark of BASF

Storage Class

11 - Combustible Solids

wgk

WGK 1

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Certificates of Analysis (COA)

Lot/Batch Number
BCCK1944
BCCF6791
BCCB9442
BCBW8463
BCBT6082

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Jianan Shen et al.
Biomaterials, 34(5), 1581-1590 (2012-11-14)
The metastasis of breast cancer is the leading cause of cancer death in women, and the lung is a common location of a secondary tumor that has metastasized from the primary source tumor. In this work, an attempt to simultaneously
Irshad A Wani et al.
Colloids and surfaces. B, Biointerfaces, 101, 243-250 (2012-09-27)
Silver nanoparticles have been synthesized in the inverse microemulsions formed using three different surfactants viz., cetyl-trimethyl ammonium bromide (CTAB), Tergitol and Triton X-100. We have done a systematic study of the effect of the surfactants on the particle size and
Neeta Jain-Gupta et al.
FEMS immunology and medical microbiology, 66(3), 436-444 (2012-11-21)
Brucellosis is the most common zoonotic disease worldwide, and there is no vaccine for human use. Brucella melitensis Rev1, a live attenuated strain, is the commercial vaccine for small ruminants to prevent B. melitensis infections but has been associated with abortions
Yanbin Guan et al.
Archives of pharmacal research, 34(10), 1719-1728 (2011-11-15)
The aim of the present study was to evaluate the effect of pluronic P123 (P123) and pluronic F127 (F127) on intestinal P-glycoprotein (P-gp) and cytochrome P450 3A using the specific substrates rhodamine-123 (R-123) and midazolam, respectively. Caco-2 cells and everted
Xijun Zhang et al.
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 31(6), 842-845 (2011-12-17)
This study examined the effect of P85 (a pluronic block copolymer) and microbubble (MB) ultrasound contrast agents under ultrasound irradiation on gene transfection and expression. The pEGFP plasmids that can encode enhanced green fluorescent protein (pEGFP) served as a report
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