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Merck

A9810

Amyloid β Protein Fragment 1-42

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About This Item

Empirical Formula (Hill Notation):
C203H311N55O60S
CAS Number:
107761-42-2
Molecular Weight:
4514.04
UNSPSC Code:
12352202
NACRES:
NA.32
MDL number:
MFCD00163049

Key Documents

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SMILES string

S(CC[C@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(

InChI

1S/C203H311N55O60S/c1-28-106(20)164(195(310)220-91-149(267)228-130(71-98(4)5)181(296)238-129(66-70-319-27)179(294)251-158(100(8)9)193(308)218-87-146(264)215-88-151(269)250-160(102(12)13)198(313)255-163(105(18)19)199(314)258-165(107(21)29-2)200(315)227-112

InChI key

DZHSAHHDTRWUTF-SIQRNXPUSA-N

assay

≥95% (HPLC)

form

powder

UniProt accession no.

P05067

storage temp.

−20°C

Quality Level

200

Gene Information

human ... APP(351)

General description

Amyloid β Protein is produced from amyloid-β precursor protein (APP). It consists of two C terminal variants, such as a long tailed Aβ 1-42 and a short tailed Aβ 1-40. APP is located on human chromosome 21q21.3.

Application

Amyloid β Protein Fragment 1-42 has been used:
  • for the preparation of Aβ 1-42 oligomer
  • for western blot analysis
  • for the interference test of immunomagnetic reduction (IMR) plasma Aβ42 assay
  • to study the effects of resveratrol on Aβ 1-42-induced impairment of spatial learning, memory and synaptic plasticity
  • to investigate the effect of Aβ in epithelial cell culture

Biochem/physiol Actions

The predominant fragment of amyloid β-protein found in the brains of patients with Alzheimer′s disease and Down′s syndrome.
Amyloid β Protein Fragment 1-42 (Aβ 1-42) has antioxidant and neuroprotective properties. Accumulation of amyloid β Protein is associated with Alzheimer′s disease (AD) and Down Syndrome. Aβ 1-42 regulates cholesterol transport and may function as a transcription factor. It may possess anti-inflammatory and antimicrobial properties.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000453555
0000453555
0000388520
0000387190
0000368432

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Functional activity of the novel Alzheimer's amyloid beta-peptide interacting domain (AbetaID) in the APP and BACE1 promoter sequences and implications in activating apoptotic genes and in amyloidogenesis
Bailey JA, et al.
Gene, 488(1), 13-22 (2011)
A novel function of monomeric amyloid beta-protein serving as an antioxidant molecule against metal-induced oxidative damage
Zou K, et al.
The Journal of Neuroscience, 22(12), 4833-4841 (2002)
Antimicrobial properties of amyloid peptides
Kagan BL, et al.
Molecular Pharmaceutics, 9(4), 708-717 (2011)
Plasma Amyloid-beta(Abeta 42) Correlates with Cerebrospinal Fluid Abeta 42 in Alzheimer?s Disease
Teunissen CE, et al.
Journal of Alzheimer'S Disease, 1-7 (2018)
Jeremy D Baker et al.
PLoS biology, 15(6), e2001336-e2001336 (2017-06-28)
The accumulation of amyloidogenic proteins is a pathological hallmark of neurodegenerative disorders. The aberrant accumulation of the microtubule associating protein tau (MAPT, tau) into toxic oligomers and amyloid deposits is a primary pathology in tauopathies, the most common of which
View All Related Papers

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