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B8660

BICINE

Name: BICINE
Brand: SIGMA

BioXtra, ≥99% (titration)

Synonym(s):

N,N-Bis(2-hydroxyethyl)glycine

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About This Item

Empirical Formula (Hill Notation):

C₆H₁₃NO₄

CAS Number:

150-25-4

Molecular Weight:

163.17

UNSPSC Code:

12161700

NACRES:

NA.25

PubChem Substance ID:

24892086

EC Number:

205-755-1

Beilstein/REAXYS Number:

1769362

MDL number:

MFCD00004295

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product line

BioXtra

Quality Level

400

assay

≥99% (titration)

form

powder

impurities

≤0.005% Phosphorus (P), ≤0.1% Insoluble matter

ign. residue

≤0.1%

pH

4.0-6.0 (1 M in H₂O)

useful pH range

7.6-9.0

pKa (25 °C)

8.3

solubility

H₂O: 1 M, clear, colorless

anion traces

chloride (Cl^-): ≤0.05%, sulfate (SO₄^2-): ≤0.05%

cation traces

Al: ≤0.0005%, Ca: <0.001%, Cu: ≤0.0005%, Fe: ≤0.0005%, K: ≤0.005%, Mg: ≤0.0005%, NH₄⁺: ≤0.05%, Na: ≤0.005%, Pb: ≤0.001%, Zn: ≤0.0005%

absorption

≤0.05 at 260 in H₂O at 1 M, ≤0.05 at 280 in H₂O at 1 M

application(s)

advanced drug delivery
diagnostic assay manufacturing

storage temp.

room temp

SMILES string

OCCN(CCO)CC(O)=O

InChI

1S/C6H13NO4/c8-3-1-7(2-4-9)5-6(10)11/h8-9H,1-5H2,(H,10,11)

InChI key

FSVCELGFZIQNCK-UHFFFAOYSA-N

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Related Categories

Biochemicals

Biological Buffers

High-Purity Biochemicals and Reagents

Application

Recommended buffer for low temperature biochemical work. Used in the preparation of stable substrate solution for serum guanase determination. Spacer in plasma protein fractionation with Sephadex^® by isotachophoresis.

Legal Information

Sephadex is a registered trademark of Cytiva

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Impact of ligand protonation on higher-order metal complexation kinetics in aqueous systems.

Raewyn M Town et al.

The journal of physical chemistry. A, 112(12), 2563-2571 (2008-03-04)

The impact of ligand protonation on the complexation kinetics of higher-order complexes is quantitatively described. The theory is formulated on the basis of the usual situation for metal complex formation in aqueous systems in which the exchange of water for

Irradiation inactivation analysis of acetylcholinesterase and the effect of buffer salts.

D Parkinson et al.

Radiation research, 90(2), 252-259 (1982-05-01)

Thermodynamic study of the second-stage dissociation of N,N-bis-(2-hydroxyethyl)glycine (bicine) in water at different ionic strength and different solvent mixtures.

Mohamed Taha

Annali di chimica, 94(12), 971-978 (2005-02-04)

The second stage dissociation constant pK2 of N,N-bis-(2-hydroxyethyl)glycine (bicine) has been determined in aqueous solution at different ionic strengths and different temperatures, using pH-metric technique. The thermodynamic quantities (deltaG(o), deltaH(o), and deltaS(o)) have been studied and discussed. Evaluation of the

Adverse effects of artificial buffers on contractile responses of arterial and venous smooth muscle.

B M Altura et al.

British journal of pharmacology, 69(2), 207-214 (1980-06-01)

1 In vitro studies were undertaken on rat aortic strips and portal vein segments in order to determine whether or not several commonly used artificial buffers, i.e., tris(hydroxymethyl) aminomethane (Tris), N-2-hydroxyethylpiperazine-N'-2-ethanesulphonic acid (HEPES), morpholine propanesulphonic acid (MOPS), N,N bis(2-hydroxyethyl) glycine

Investigation of a primary requirement of organ preservation solutions: supplemental buffering agents improve hepatic energy production during cold storage.

T A Churchill et al.

Transplantation, 65(4), 551-559 (1998-03-21)

This study was designed to investigate the effects of a modified University of Wisconsin (UW) solution supplemented with one of four buffering agents (histidine, bicine [N,N-bis(2-hydroxyethyl)glycine], tricine [N-tris(hydroxymethyl)methylglycine], and Tris) on liver metabolism during cold ischemic storage. Rat livers were

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