D5767
2,2′-Dithiodipyridine
powder
Synonym(s):
2,2′-Dipyridyl disulfide
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About This Item
Empirical Formula (Hill Notation):
C10H8N2S2
CAS Number:
Molecular Weight:
220.31
UNSPSC Code:
12352112
NACRES:
NA.26
PubChem Substance ID:
EC Number:
218-343-1
Beilstein/REAXYS Number:
154629
MDL number:
Product Name
2,2′-Dithiodipyridine, powder
InChI key
HAXFWIACAGNFHA-UHFFFAOYSA-N
InChI
1S/C10H8N2S2/c1-3-7-11-9(5-1)13-14-10-6-2-4-8-12-10/h1-8H
SMILES string
S(Sc1ccccn1)c2ccccn2
form
powder
mp
56-58 °C (lit.)
storage temp.
2-8°C
Quality Level
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Application
2,2′-Dithiodipyridine has been used in the reconstitution of the reduced interchain disulfide bonds of monolconal antibodies. It may be used as a medium component for T cell hybridoma cell culture and as thiol crosslinking agent.
Biochem/physiol Actions
2,2′-Dithiodipyridine mediates inter-unit disulfide cross-linking. It interacts with carbon nucleophiles to yield thiopyridyl derivatives.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
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eEROS (Encyclopedia of Reagents for Organic Synthesis) (2005)
Oxidation of a critical thiol residue of the adenine nucleotide translocator enforces Bcl-2-independent permeability transition pore opening and apoptosis.
Costantini P, et al.
Oncogene (2000)
Peptide-unit assembling using disulfide cross-linking: a new approach for construction of protein models
Futaki S and Kitagawa K
Tetrahedron Letters, 35(8), 1267-1270 (1994)
Human T cells resistant to complement lysis by bivalent antibody can be efficiently lysed by dimers of monovalent antibody
Nielsen SU and Routledge EG
Blood, 100(12), 4067-4073 (2002)
T L Dutka et al.
The Journal of physiology, 589(Pt 9), 2181-2196 (2010-12-01)
S-Nitrosoglutathione (GSNO) is generated in muscle and may S-glutathionylate and/or S-nitrosylate various proteins involved in excitation–contraction (EC) coupling, such as Na+-K+-ATPases, voltage-sensors (VSs) and Ca2+ release channels (ryanodine receptors,RyRs), possibly changing their properties. Using mechanically skinned fibres from rat extensor
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