G7877

Glucose-6-phosphate Dehydrogenase from baker′s yeast (S. cerevisiae)

Name: Glucose-6-phosphate Dehydrogenase from baker′s yeast (<I>S. cerevisiae</I>)
Brand: SIGMA

Type VII, ammonium sulfate suspension, ≥200 units/mg protein

Synonym(s):

glucose-6-phosphate dehydrogenase (NADP+), G-6-P-DH, Zwischenferment

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About This Item

CAS Number:

9001-40-5

UNSPSC Code:

12352204

NACRES:

NA.54

EC Number:

232-602-6

MDL number:

MFCD00081656

EC Number:

1.1.1.49 (BRENDA, IUBMB)

Product Name

Glucose-6-phosphate Dehydrogenase from baker′s yeast (S. cerevisiae), Type VII, ammonium sulfate suspension, ≥200 units/mg protein

biological source

bakers yeast

type

Type VII

form

ammonium sulfate suspension

specific activity

≥200 units/mg protein

mol wt

128 kDa

technique(s)

cell based assay: suitable

solubility

water: soluble

application(s)

diagnostic assay manufacturing

storage temp.

2-8°C

Quality Level

200

Gene Information

Saccharomyces cerevisiae ... ZWF1(855480)

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Related Categories

Chemistry & Biochemicals

Phosphates

Application

Glucose-6-phosphate dehydrogenase has been used in a study to investigate the effect of dehydroepiandrosterone on cell growth and mitochondrial function in TM-3 cells. Glucose-6-phosphate dehydrogenase has also been used in a study to investigate the incidence of apoptosis and transcript abundance in bovine follicular cells. Glucose-6-phosphate dehydrogenase is used to test ketose reductase activity in developing maize endosperm.

Biochem/physiol Actions

Glucose-6-phosphate dehydrogenase catalyzes the conversion of glucose-6-phosphate to 6-phosphogluconolacetone as the first step in the pentose phosphate pathway.

General description

Glucose 6-phosphate dehydrogenase (G-6-P-DH) is a key regulatory enzyme in the first step of the pentose phosphate pathway. G-6-P-DH is a glycoprotein with a molecular mass of 128 kDa (gel filtration).

Other Notes

One unit will oxidize 1.0 μmole of D-glucose 6-phosphate to 6-phospho-D-gluconate per min in the presence of NADP at pH 7.4 at 25 °C.

Physical form

Crystalline suspension in 3.2 M (NH₄)₂SO₄ solution, pH 7.0

pictograms

GHS08

signalword

Danger

hcodes

H334

pcodes

P261 - P284 - P501

Hazard Classifications

Resp. Sens. 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Chapter 18 - Pharmacodynamic Pharmacogenomics

McCallum L, et al.

Handbook of Pharmacogenomics and Stratified Medicine, 8(12), 365-383 (2014)

Alcohol and gastrointestinal tract function

Bhardwaj SB

Bioactive Food as Dietary Interventions for Arthritis and Related Inflammatory Diseases, 81-81 (2012)

Alpha-ketoglutarate partially alleviates effects of high-fat high-fructose diet in mouse muscle

Vatashchuk MV, et al.

EXCLI Journal , 1264-1277 (2023)

Effect of dehydroepiandrosterone on cell growth and mitochondrial function in TM-3 cells.

Xuehuai Shen et al.

General and comparative endocrinology, 177(1), 177-186 (2012-04-03)

Dehydroepiandrosterone (DHEA), a major steroid hormone, decreases with age, and this reduction has been shown to be associated with physical health. In the present study, the effect of DHEA on cell growth and mitochondrial function was investigated using TM-3 cells

Knockdown of glucose-6-phosphate dehydrogenase (G6PD) following cerebral ischemic reperfusion: the pros and cons.

Gang Zhao et al.

Neurochemistry international, 61(2), 146-155 (2012-05-15)

NADPH derived from glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme of the pentose phosphate pathway, has been implicated not only to promote reduced glutathione (GSH) but also enhance oxidative stress in specific cellular conditions. In this study, the effects of G6PD

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