I6138
Idazoxan hydrochloride
α2-adrenoceptor antagonist
Synonym(s):
(±)-2-[1,4-Benzodioxan-2-yl]-2-imidazoline hydrochloride, RX 781094
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About This Item
Empirical Formula (Hill Notation):
C11H12N2O2 · HCl
CAS Number:
Molecular Weight:
240.69
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Quality level:
Product Name
Idazoxan hydrochloride,
Quality Level
solubility
H2O: 50 mg/mL
SMILES string
Cl.C1CN=C(N1)C2COc3ccccc3O2
InChI
1S/C11H12N2O2.ClH/c1-2-4-9-8(3-1)14-7-10(15-9)11-12-5-6-13-11;/h1-4,10H,5-7H2,(H,12,13);1H
InChI key
MYUBYOVCLMEAOH-UHFFFAOYSA-N
Gene Information
human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)
Application
Idazoxan hydrochloride has been used to study the efficacy of antidepressant treatments that interact with multiple neurotransmitter systems.
Biochem/physiol Actions
α2-adrenoceptor antagonist; I2 imidazoline receptor agonist; I1 imidazoline receptor antagonist. Idazoxan can antagonize various behaviors generated by ethanol in a preclinical setting. It possesses neuroprotective activity against spinal cord injury, resulted due to experimental autoimmune encephalomyelitis (EAE) in mouse, an animal modal of multiple sclerosis (MS).
signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 3 Oral
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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Product Information Sheet
Sidney P Kuo et al.
Neuron, 71(2), 306-318 (2011-07-28)
Inhibitory interneurons across diverse brain regions commonly exhibit spontaneous spiking activity, even in the absence of external stimuli. It is not well understood how stimulus-evoked inhibition can be distinguished from background inhibition arising from spontaneous firing. We found that noradrenaline
Effects of idazoxan on alcohol pharmacokinetics and intoxication: a preliminary human laboratory study
Haass-Koffler C L, et al.
Alcohol, 39(4), 594-602 (2015)
Valerio Mammoli et al.
Bioorganic & medicinal chemistry, 20(7), 2259-2265 (2012-03-01)
Aim of the present study was to obtain novel α(2)-adrenoreceptor (α(2)-AR) antagonists, possibly endowed with subtype-selectivity. Therefore, inspired by the non subtype-selective α(2)-AR antagonist idazoxan, we designed 1,4-dioxane derivatives bearing an aromatic area in position 5 or 6 and the