L5288
Latrunculin B
from Latruncula magnifica, ≥80% (HPLC), solid, actin polymerization inhibitor
Synonym(s):
LAT-B
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About This Item
Empirical Formula (Hill Notation):
C20H29NSO5
CAS Number:
Molecular Weight:
395.51
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Product Name
Latrunculin B from Latruncula magnifica, ≥80% (HPLC), solid
Quality Level
assay
≥80% (HPLC)
form
solid
mol wt
395.5
solubility
ethanol: soluble
storage temp.
−20°C
SMILES string
C[C@H]1CC[C@@H]2C[C@H](C[C@@](O)(O2)[C@@H]3CSC(=O)N3)OC(=O)C=C(C)CCC=C1
InChI
1S/C20H29NO5S/c1-13-5-3-4-6-14(2)9-18(22)25-16-10-15(8-7-13)26-20(24,11-16)17-12-27-19(23)21-17/h3,5,9,13,15-17,24H,4,6-8,10-12H2,1-2H3,(H,21,23)/b5-3-,14-9-/t13-,15-,16-,17+,20-/m1/s1
InChI key
NSHPHXHGRHSMIK-JRIKCGFMSA-N
General description
Latrunculin B is a macrocyclic toxin, which is produced by Latruncula magnifica.
Application
Latrunculin B from Latruncula magnifica has been used for actin depolymerisation in various experiments. It has also been used as a component in bone marrow-derived dendritic cell (BMDC) complete medium, to study the formation of tubules from phagosomes in dendritic cells.
Biochem/physiol Actions
Latrunculin B inhibits actin polymerization in vitro. Latrunculin B disrupts microfilament-mediated processes.
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Warchal SJ, et al.
Assay and Drug Development Technologies, 14(7), 395-406 (2016)