LO3300
LOPAC®1280 (International Version)
Synonym(s):
Library of Pharmacologically Active Compounds
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About This Item
NACRES:
NA.77
UNSPSC Code:
41106609
Form:
liquid
Quality level:
form
liquid
Quality Level
drug control
Új pszichoaktív anyag / New psychoactive substance (Hungary), 78/2022. (XII. 28.) BM rendelet
shipped in
dry ice
storage temp.
−20°C
General description
Compounds are arranged in 96-well format in 16 racks of 80, one compound per well (250 μl at 10 mM in DMSO in archival storage racks).
Application
LOPAC®1280 (International Version) has been used to screen chemical inhibitors with dephosphorylation activity. It has also been used in MyoScreen myotubes to screen for muscle regeneration molecules.
Features and Benefits
Collection of approximately 1,280 pharmacologically active Sigma compounds.
Includes the latest, drug-like molecules in the fields of Cell Signaling & Neuroscience:
- Apotosis
- G Proteins & Cyclic Nucleotides
- Gene Regulation & Expression
- Ion Channels
- Lipid Signaling
- Multi-drug Resistance
- Neurotransmission
- Phosphorylation
SDFile provided to construct a database containing:
- Structure
- Primary Name
- Secondary Name
- Pharmacological Activity
- Sigma-RBI Product Number (for easy re-order)
- Rack Position
Other Notes
For sale outside of the U.S. only. U.S. customers should refer to Product Code LO1280.
Legal Information
LOPAC is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Danger
Hazard Classifications
Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1A - Eye Dam. 1 - Lact. - Muta. 1B - Repr. 1A - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1 - STOT RE 2 - STOT SE 2
Storage Class
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
flash_point_f
188.6 °F - closed cup
flash_point_c
87 °C - closed cup
wgk
WGK 3
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Temperature-sensitive substrate and product binding underlie temperature-compensated phosphorylation in the clock
Shinohara Y, et al.
Molecular Cell, 67(5), 783-798 (2017)
MyoScreen, a High-Throughput Phenotypic Screening Platform Enabling Muscle Drug Discovery
Young J, et al.
SLAS discovery, 23(8), 790-806 (2018)
Jaime Freitas et al.
Current chemical genomics and translational medicine, 8, 36-46 (2014-04-29)
To adapt the use of GH3.TRE-Luc reporter gene cell line for a quantitative high-throughput screening (qHTS) platform, we miniaturized the reporter gene assay to a 1536-well plate format. 1280 chemicals from the Library of Pharmacologically Active Compounds (LOPAC) and the