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P3953

L-α-Phosphatidyl-D-myo-inositol 3-monophosphate, dipalmitoyl

Name: <SC>L</SC>-α-Phosphatidyl-<SC>D</SC>-<I>myo</I>-inositol 3-monophosphate, dipalmitoyl
Brand: SIGMA

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About This Item

Empirical Formula (Hill Notation):

C₄₁H₈₀O₁₆P₂

CAS Number:

165689-81-6

Molecular Weight:

891.01

NACRES:

NA.77

PubChem Substance ID:

24898473

UNSPSC Code:

12352207

MDL number:

MFCD02259146

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Properties

solubility

DMSO: soluble, chloroform: soluble, ethanol: soluble

storage temp.

−20°C

SMILES string

CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OP(O)(O)=O)[C@H]1O)OC(=O)CCCCCCCCCCCCCCC

InChI

1S/C41H80O16P2/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-34(42)53-31-33(55-35(43)30-28-26-24-22-20-18-16-14-12-10-8-6-4-2)32-54-59(51,52)57-41-38(46)36(44)37(45)40(39(41)47)56-58(48,49)50/h33,36-41,44-47H,3-32H2,1-2H3,(H,51,52)(H2,48,49,50)/t33-,36+,37+,38-,39-,40-,41+/m1/s1

InChI key

SZPQTEWIRPXBTC-KFOWTEFUSA-N

Description

General description

Component of lipid signaling pathway; product of phosphatidylinositol 3-kinase.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gbetagamma.

C L Huang et al.

Nature, 391(6669), 803-806 (1998-03-05)

Inward rectifier K+ channels, which modulate electrical activity in many cell types, are regulated by protein kinases, guanine-nucleotide-binding proteins (G proteins) and probably actin cytoskeleton. Generation of phosphatidylinositol 4,5-bisphosphate (PIP2) by ATP-dependent lipid kinases is known to activate inward rectifier

Structural characterization of the interaction between a pleckstrin homology domain and phosphatidylinositol 4,5-bisphosphate.

J E Harlan et al.

Biochemistry, 34(31), 9859-9864 (1995-08-08)

The pleckstrin homology (PH) domain is a protein module of approximately 100 amino acids that is found in several proteins involved in signal transduction [for a recent review, see Gibson et al. (1994) Trends Biochem. Sci. 19, 349-353]. Although the

Pleckstrin homology domain-mediated membrane association and activation of the beta-adrenergic receptor kinase requires coordinate interaction with G beta gamma subunits and lipid.

J A Pitcher et al.

The Journal of biological chemistry, 270(20), 11707-11710 (1995-05-19)

The pleckstrin homology (PH) domain is an approximately 100-amino-acid region of sequence homology present in numerous proteins of diverse functions, which forms a discrete structural module. Several ligands capable of binding to PH domain-containing proteins have been identified including phosphatidylinositol