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Merck

SAB4500437

Anti-Claudin 7 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

CEPTRL2, claudin 7, claudin 9, claudin-1, claudin-7

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203

Key Documents

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Product Name

Anti-Claudin 7 antibody produced in rabbit, affinity isolated antibody

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 22 kDa

species reactivity

human, rat, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:20000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

O95471

UniProt accession no.

O95471

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... CLDN7(1366)

Related Categories

Biochem/physiol Actions

In HCC827 and NCI-H358 lung cancer cells, suppression of claudin-7 decreases the expression of integrin β1. Claudins are important constituents of tight junctions (TJ) in the upper region of epithelial cells.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

General description

Anti-Claudin 7 Antibody detects endogenous levels of total Claudin 7 protein.
Claudin 7 is a tight junction membrane protein that belongs to claudins (cld) family. It is upregulated at high level in the upper gastrointestinal tract and the liver. It is located on human chromosome 17p13.

Immunogen

The antiserum was produced against synthesized peptide derived from human Claudin 7.

Immunogen Range: 162-211

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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Storage Class

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
310153

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The claudins
Lal-Nag M and Morin P J
Genome Biology (2009)
Harold Love et al.
Tissue engineering. Part A, 26(19-20), 1091-1098 (2020-04-22)
Patient-oriented applications of cell culture include cell therapy of organ failure like chronic renal failure. Clinical deployment of a cell-based device for artificial renal replacement requires qualitative and quantitative fidelity of a cultured cell to its in vivo counterpart. Active
Sijo Mathew et al.
Development (Cambridge, England), 144(22), 4148-4158 (2017-10-11)
Kidney collecting system development requires integrin-dependent cell-extracellular matrix interactions. Integrins are heterodimeric transmembrane receptors consisting of α and β subunits; crucial integrins in the kidney collecting system express the β1 subunit. The β1 cytoplasmic tail has two NPxY motifs that
A non-tight junction function of claudin-7-Interaction with integrin signaling in suppressing lung cancer cell proliferation and detachment
Lu Z, et al.
Molecular Cancer (2015)
The importance of claudin-7 palmitoylation on membrane subdomain localization and metastasis-promoting activities
Heiler S, et al.
Cell communication and signaling : CCS (2015)

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