SML0370
Kartogenin
≥98% (HPLC), runt-related transcription factor 1 (RUNX1) regulator, powder
Synonym(s):
2-[(Biphenyl-4-yl)carbamoyl]benzoic acid, 4′-Phenyl-phthalanilic acid (8CI), KGN
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About This Item
Empirical Formula (Hill Notation):
C20H15NO3
CAS Number:
Molecular Weight:
317.34
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Product Name
Kartogenin, ≥98% (HPLC)
SMILES string
O=C(NC1=CC=C(C2=CC=CC=C2)C=C1)C(C=CC=C3)=C3C(O)=O
InChI
1S/C20H15NO3/c22-19(17-8-4-5-9-18(17)20(23)24)21-16-12-10-15(11-13-16)14-6-2-1-3-7-14/h1-13H,(H,21,22)(H,23,24)
InChI key
SLUINPGXGFUMLL-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
solubility
DMSO: >15 mg/mL
storage temp.
room temp
Quality Level
Related Categories
Biochem/physiol Actions
Kartogenin induces the selective differentiation of multipotent mesenchymal stem cells (MSCs) into chondrocytes.
Kartogenin induces the selective differentiation of multipotent mesenchymal stem cells (MSCs) into chondrocytes. Kartogenin binds to filamin A, and disrupts the specific interaction between filamin A and CBFβ (core-binding factor β subunit). Apparently, kartogenin induces chondrogenesis by regulating the nuclear localization of CBFβ.
Kartogenin is a small heterocyclic compound. It is involved in regulating runt-related transcription factor 1 (RUNX1), which plays an important role in chondrocyte proliferation and survival.
Storage Class
11 - Combustible Solids
wgk
WGK 3
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