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Merck

SML0810

MHY1485

≥95% (HPLC), mTOR activator, powder

Synonym(s):

4,6-Di-4-morpholinyl-N-(4-nitrophenyl)-1,3,5-triazin-2-amine

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About This Item

Empirical Formula (Hill Notation):
C17H21N7O4
CAS Number:
326914-06-1
Molecular Weight:
387.39
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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Product Name

MHY1485, ≥95% (HPLC)

SMILES string

[N+](=O)([O-])c1ccc(cc1)Nc2nc(nc(n2)N4CCOCC4)N3CCOCC3

InChI

1S/C17H21N7O4/c25-24(26)14-3-1-13(2-4-14)18-15-19-16(22-5-9-27-10-6-22)21-17(20-15)23-7-11-28-12-8-23/h1-4H,5-12H2,(H,18,19,20,21)

InChI key

MSSXBKQZZINCRI-UHFFFAOYSA-N

assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

Quality Level

100

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Application

MHY1485 has been used:
  • to study the effect of mammalian target of rapamycin mTOR signalling on in vitro O-GlcNAcylation
  • to inhibit autophagy
  • as a mTOR agonist to demonstrate that the O-linked N-acetylglucosamine transferase- RNA helicase p68 (OGT-DDX5) axis regulates colorectal cancer cell proliferation and metastasis

Biochem/physiol Actions

MHY1485 binds to the mammalian target of rapamycin (mTOR) and stimulates its action. MHY1485 has the ability to penetrate the cell. It prevents the ultraviolet-induced oxidative stress in keratinocytes and fibroblasts.
MHY1485 is mTOR activator that potently inhibits autophagy by suppression of fusion between autophagosomes and lysosomes.
MHY1485 is mTOR activator: autophagy inhibitor.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the PKB/Akt page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000518274
0000518274
0000244306
0000139853
0000139856

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Cross regulation between mTOR signaling and O-GlcNAcylation
Very N, et al.
Journal of Bioenergetics and Biomembranes, 50(3), 213-222 (2018)
Duc-Vinh Pham et al.
Journal of experimental & clinical cancer research : CR, 41(1), 9-9 (2022-01-07)
Adiponectin, the most abundant adipokine derived from adipose tissue, exhibits a potent suppressive effect on the growth of breast cancer cells; however, the underlying molecular mechanisms for this effect are not completely understood. Fatty acid metabolic reprogramming has recently been
MHY1485 ameliorates UV-induced skin cell damages via activating mTOR-Nrf2 signaling
Yang Bo, et al.
Oncotarget, 8(8), 12775-12775 (2017)
ULK1 phosphorylates Sec23A and mediates autophagy-induced inhibition of ER-to-Golgi traffic
Gan W, et al.
BMC Cell Biology, 18(1), 22-22 (2017)
O-GlcNAcylation promotes colorectal cancer progression by regulating protein stability and potential catcinogenic function of DDX5
Wu N, et al.
Journal of Cellular and Molecular Medicine, 23(2), 1354-1362 (2019)
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