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T0307

Tyloxapol

BioXtra

Synonym(s):

4-(1,1,3,3-Tetramethylbutyl)phenol polymer with formaldehyde and oxirane

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About This Item

CAS Number:
25301-02-4
NACRES:
NA.25
PubChem Substance ID:
24899881
UNSPSC Code:
12161900
MDL number:
MFCD00149002
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description

non-ionic

Quality Level

100

product line

BioXtra

impurities

<0.0005% Phosphorus (P)

ign. residue

<1.0%

CMC

0.018 mM

transition temp

cloud point 94.3 °C

anion traces

chloride (Cl-): <0.05%, sulfate (SO42-): <0.6%

cation traces

Al: <0.0005%, Ca: <0.0005%, Cu: <0.0005%, Fe: <0.001%, K: <0.005%, Mg: <0.0005%, NH4+: <0.05%, Na: <0.5%, Pb: <0.001%, Zn: <0.0005%

SMILES string

[H]C([H])=O.OCCO.CC(C)(C)CC(C)(C)c1ccc(O)cc1

InChI

1S/C14H22O.C2H6O2.CH2O/c1-13(2,3)10-14(4,5)11-6-8-12(15)9-7-11;3-1-2-4;1-2/h6-9,15H,10H2,1-5H3;3-4H,1-2H2;1H2

InChI key

GWJOFBXSBDVUMH-UHFFFAOYSA-N

General description

Tyloxapol is a biocompatible surfactant
A nonionic liquid polymer of the alkyl aryl polyether alcohol type. Used as a surfactant.

Application

Tyloxapol has been used in a study to assess the enhanced pulmonary absorption of recombinant human insulin. It has also been used in a study to investigate the metabolic pathways promoting intrahepatic fatty acid accumulation in methionine and choline deficiency.

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pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

235.4 °F - closed cup

flash_point_c

113 °C - closed cup

ppe

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
MKCR4287
MKCQ1034
MKCK7328
MKCH6508
MKCF6494

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Formulation of Tyloxapol niosomes for encapsulation, stabilization and dissolution of anti-tubercular drugs
Mehta, S. and N. Jindal
Colloids and Surfaces. B, Biointerfaces, 434?441-434?441 (2013)
Jianheng Zheng et al.
Die Pharmazie, 67(5), 448-451 (2012-07-07)
Natural pulmonary surfactant (PS) and its artificial substitute phospholipid hexadecanol tyloxapol (PHT) are effective absorption enhancers on promoting recombinant human insulin (Rh-ins) absorption in vivo, but the in vitro efficacy and underlying mechanism remains unclear. In the current study, the
David P Macfarlane et al.
American journal of physiology. Endocrinology and metabolism, 300(2), E402-E409 (2010-12-02)
The pathological mechanisms that distinguish simple steatosis from steatohepatitis (or NASH, with consequent risk of cirrhosis and hepatocellular cancer) remain incompletely defined. Whereas both a methionine- and choline-deficient diet (MCDD) and a choline-deficient diet (CDD) lead to hepatic triglyceride accumulation
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