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Merck

T2528

Terbutaline hemisulfate salt

β-adrenoceptor agonist

Synonym(s):

2-t-Butylamino-1-(3,5-dihydroxyphenyl)ethanol, 5-[2-[(1,1-Dimethylethyl)amino]-1-hydroxyethyl]-1,3-benzenediol hemisulfate salt

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About This Item

Linear Formula:
C12H19NO3 · 1/2H2SO4
CAS Number:
23031-32-5
Molecular Weight:
274.32
NACRES:
NA.77
PubChem Substance ID:
24278729
UNSPSC Code:
12352200
EC Number:
245-386-3
MDL number:
MFCD00079584

Key Documents

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Product Name

Terbutaline hemisulfate salt,

InChI

1S/2C12H19NO3.H2O4S/c2*1-12(2,3)13-7-11(16)8-4-9(14)6-10(15)5-8;1-5(2,3)4/h2*4-6,11,13-16H,7H2,1-3H3;(H2,1,2,3,4)

InChI key

KFVSLSTULZVNPG-UHFFFAOYSA-N

SMILES string

OS(O)(=O)=O.CC(C)(C)NCC(O)c1cc(O)cc(O)c1.CC(C)(C)NCC(O)c2cc(O)cc(O)c2

solubility

H2O: soluble 100 mg/mL, clear to slightly hazy, colorless to yellow

originator

Novartis

Quality Level

100

Gene Information

human ... ADRB1(153), ADRB2(154), ADRB3(155)

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Application

Terbutaline hemisulfate has been used as a reference standard for the determination of β agonist residues in meat4. It has also been used as a standard for developing LC-MS-MS based techniques for the analysis of veterinary drugs5.

Biochem/physiol Actions

Terbutaline is a β-adrenoceptor agonist and is known to function as a bronchodilator. Studies have reported that terbutaline is potent inhibitor of premature labor6.

Features and Benefits

To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Preparation Note

Terbutaline hemisulfate salt dissolves in water at 100 mg/ml to yield a colorless to yellow, clear to slightly hazy solution.

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H361,H370

Hazard Classifications

Repr. 2 - STOT SE 1

target_organs

Cardio-vascular system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN4064
BCCJ7739
BCCC7481
BCBV3715
BCBQ7406V

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I Ingemarsson
American journal of obstetrics and gynecology, 125(4), 520-524 (1976-06-15)
The effect of terbutaline, a "selective" beta2-receptor stimulator, was compared with that of placebo in 30 patients in premature labor. Treatment consisted of an intravenous infusion for at least 8 hours, and then of subcutaneous injections four times daily for
Theodore A Slotkin et al.
Neurotoxicology and teratology, 36, 91-96 (2012-07-21)
Terbutaline, a β2-adrenoceptor agonist, is used off-label for long-term management of preterm labor; such use is associated with increased risk of neurodevelopmental disorders, including autism spectrum disorders. We explored the mechanisms underlying terbutaline's effects on development of peripheral sympathetic projections
Jodie M Dodd et al.
The Cochrane database of systematic reviews, 12, CD003927-CD003927 (2012-12-14)
Some women who have threatened to give birth prematurely, subsequently settle. They may then take oral tocolytic maintenance therapy to prevent preterm birth and to prolong gestation. To assess the effects of oral betamimetic maintenance therapy after threatened preterm labour
Anthony M J Sanchez et al.
European journal of applied physiology, 113(2), 411-418 (2012-07-07)
This study aimed to investigate the effects on a possible improvement in aerobic and anaerobic performance of oral terbutaline (TER) at a supra-therapeutic dose in 7 healthy competitive male athletes. On day 1, ventilatory threshold, maximum oxygen uptake [Formula: see
Andrew H Travers et al.
The Cochrane database of systematic reviews, 12, CD010179-CD010179 (2012-12-14)
Inhaled beta-agonist therapy is central to the management of acute asthma. This review evaluates the benefit of an additional use of intravenous beta(2)-agonist agents. To determine the benefit of adding intravenous (IV) beta(2)-agonists to inhaled beta(2)-agonist therapy for acute asthma
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