739944
Resomer® RG 504, Poly(D,L-lactide-co-glycolide)
lactide:glycolide 50:50, ester terminated, Mw 38,000-54,000
Synonym(s):
PLGA
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About This Item
Linear Formula:
[C3H4O2]x[C2H2O2]y
CAS Number:
MDL number:
UNSPSC Code:
12162002
NACRES:
NA.23
SMILES string
O2C(C(=O)OC(C2=O)C)C.O1CC(=O)OCC1=O
InChI
1S/C6H8O4.C4H4O4/c1-3-5(7)10-4(2)6(8)9-3;5-3-1-7-4(6)2-8-3/h3-4H,1-2H3;1-2H2
InChI key
LCSKNASZPVZHEG-UHFFFAOYSA-N
form
amorphous
feed ratio
lactide:glycolide 50:50
mol wt
Mw 38,000-54,000
degradation timeframe
<3 months
viscosity
0.45-0.60 dL/g, 0.1 % (w/v) in chloroform(25 °C, Ubbelohde) (size 0c glass capillary viscometer)
transition temp
Tg 46-50 °C
storage temp.
2-8°C
Quality Level
Related Categories
Application
Resomer® RG 504, Poly(ᴅ,ʟ-lactide-co-glycolide) can be used to prepare polymeric nanoparticles that are effective carriers for anti-cancer natural substances.
Poly(D, L-lactide-co-glycolide)microspheres can be used to fabricate a hemostatic delivery device forthrombin.
Poly(D, L-lactide-co-glycolide)microspheres can be used to fabricate a hemostatic delivery device forthrombin.
Features and Benefits
Controlled release of bioactive agents, sutures and bioabsorbable implantable devices.
Legal Information
Product of Evonik
RESOMER is a registered trademark of Evonik Rohm GmbH
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Ananthakrishnan Soundaram Jeevarathinam et al.
Angewandte Chemie (International ed. in English) (2019-12-17)
We report a new approach to monitor drug release from nanocarriers via a paclitaxel-methylene blue conjugate (PTX-MB) with redox activity. This construct is in a photoacoustically silent reduced state inside poly(lactic-co-glycolic acid) (PLGA) nanoparticles (PTX-MB@PLGA NPs). During release, PTX-MB is
Mani Gajendiran et al.
Colloids and surfaces. B, Biointerfaces, 104, 107-115 (2013-01-10)
A series of biodegradable low molecular weight PLGA-PEG-PLGA tri-block copolymers have been synthesized in powder form. The anti-tuberculosis drug Isoniazid (INH) loaded polymeric core-shell nanoparticles (CSNPs) have been prepared by sonication followed by water-in-oil-in-water (w/o/w) double emulsification technique. The nanoparticles
Rongcai Liang et al.
International journal of pharmaceutics, 454(1), 344-353 (2013-07-23)
Peptide or protein degradation often occurs when water flows into the dosage form. The aim of this study was to investigate the effect of water on exenatide acylation in poly(lactide-co-glycolide) (PLGA) microspheres. Exenatide-loaded PLGA microspheres were incubated at different relative
Jingwei Tian et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 52, 143-152 (2012-11-21)
Continuous dopaminergic stimulation (CDS) is an important drug development strategy in the treatment of Parkinson's disease (PD). Rotigotine is a non-ergoline D(3)/D(2)/D(1) dopamine receptor agonist for treating PD. As a new treatment option for CDS, rotigotine-loaded microspheres (RoMS), long-acting sustained-release
Patrick Vavken et al.
Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association, 29(1), 122-132 (2012-12-04)
The objective of this study was to assess the effect of absorbable or nonabsorbable sutures in bioenhanced anterior cruciate ligament (ACL) repair in a skeletally immature pig model on suture tunnel and growth plate healing and biomechanical outcomes. Sixteen female
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