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Merck

84210

Salicylic acid

≥99.0% (T), powder, puriss. p.a.

Synonym(s):

2-Hydroxybenzoic acid

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About This Item

Linear Formula:
2-(HO)C6H4CO2H
CAS Number:
Molecular Weight:
138.12
NACRES:
NA.21
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
200-712-3
MDL number:
Beilstein/REAXYS Number:
774890

Product Name

Salicylic acid, puriss. p.a., ≥99.0% (T)

SMILES string

OCc1ccccc1
OC(=O)c1ccccc1O

InChI key

YGSDEFSMJLZEOE-UHFFFAOYSA-N

InChI

1S/C7H6O3/c8-6-4-2-1-3-5(6)7(9)10/h1-4,8H,(H,9,10)

vapor density

4.8 (vs air)

vapor pressure

1 mmHg ( 114 °C)

grade

puriss. p.a.

assay

≥99.0% (T)

form

powder

ign. residue

≤0.05% (as SO4)

loss

≤0.5% loss on drying

bp

211 °C (lit.)

mp

158-161 °C (lit.)
158-161 °C

solubility

96% ethanol: 0.1 g/mL, clear

anion traces

chloride (Cl-): ≤100 mg/kg
sulfate (SO42-): ≤200 mg/kg

cation traces

Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤50 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Na: ≤500 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Zn: ≤5 mg/kg

Quality Level

Gene Information

human ... ALB(213), PTPN1(5770)

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Application

Salicylic acid may be used for the quantitative estimation of nitrate in plant materials by colorimetric method. It may be used in the synthesis of 2,5-dihydroxybenzoic acid (gentistic acid).

General description

Salicylic acid is an aromatic phenolic derivative. It plays an important role in various physiological processes in plants, such as thermogenesis, ethylene synthesis and fruit ripening.

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Repr. 2

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

314.6 °F - closed cup

flash_point_c

157 °C - closed cup

ppe

dust mask type N95 (US), Eyeshields, Gloves


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Salicylic acid activates nitric oxide synthesis in Arabidopsis.
Zottini M, et al.
Journal of Experimental Botany, 58(6), 1397-1405 (2007)
Rapid colorimetric determination of nitrate in plant tissue by nitration of salicylic acid1.
Cataldo DA, et al.
Communications in Soil Science and Plant Analysis, 6(1), 71-80 (1975)
Eagleson M.
Concise Encyclopedia Chemistry, 449-449 (1994)
Michal Harel et al.
Cell, 179(1), 236-250 (2019-09-10)
Immunotherapy has revolutionized cancer treatment, yet most patients do not respond. Here, we investigated mechanisms of response by profiling the proteome of clinical samples from advanced stage melanoma patients undergoing either tumor infiltrating lymphocyte (TIL)-based or anti- programmed death 1
E Benfeldt et al.
Acta dermato-venereologica, 79(5), 338-342 (1999-09-24)
Our aim was to simultaneously investigate 2 techniques for in vivo sampling of peripheral compartment pharmacokinetics after systemic administration of acetylsalicylic acid. Ten volunteers were given 2 g acetylsalicylic acid orally. Blood samples and dialysates from 4 microdialysis probes inserted

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