E5406
Ethopropazine hydrochloride
≥98% (HPLC), butyrylcholinesterase inhibitor, powder
Synonym(s):
10-(2-Diethylaminopropyl)phenothiazine, 10-[2-(Diethylamino)propyl]phenothiazine hydrochloride, Dibutil hydrochloride, Parkin
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About This Item
Empirical Formula (Hill Notation):
C19H24N2S · HCl
CAS Number:
Molecular Weight:
348.93
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
214-134-4
MDL number:
Product Name
Ethopropazine hydrochloride, ≥98% (HPLC), powder
Quality Level
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white
solubility
DMSO: >5 mg/mL at ~60 °C, clear
storage temp.
2-8°C
SMILES string
Cl[H].CCN(CC)C(C)CN1c2ccccc2Sc3ccccc13
InChI
1S/C19H24N2S.ClH/c1-4-20(5-2)15(3)14-21-16-10-6-8-12-18(16)22-19-13-9-7-11-17(19)21;/h6-13,15H,4-5,14H2,1-3H3;1H
InChI key
VXPCQISYVPFYRK-UHFFFAOYSA-N
Gene Information
human ... CHRM1(1128)
General description
Ethopropazine hydrochloride possess anticholinergic, antihistamine and antiadrenergic properties.
Biochem/physiol Actions
Ethoproprazine hydrochloride is an inhibitor of butyrylcholinesterase; antiparkinsonian
Ethoproprazine hydrochloride is an inhibitor of butyrylcholinesterase; antiparkinsonian. It reduces extrapyramidal motor effects, characteristic of Parkinson′s disease; also alleviates thermal hyperalgesia in rats.
Features and Benefits
This compound is featured on the Acetylcholine Synthesis and Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Grace G Y Lim et al.
PloS one, 8(9), e73235-e73235 (2013-09-12)
Disruption of the ubiquitin-proteasome system, which normally identifies and degrades unwanted intracellular proteins, is thought to underlie neurodegeneration. Supporting this, mutations of Parkin, a ubiquitin ligase, are associated with autosomal recessive parkinsonism. Remarkably, Parkin can protect neurons against a wide
Kei Okatsu et al.
Nature communications, 3, 1016-1016 (2012-08-23)
Dysfunction of PINK1, a mitochondrial Ser/Thr kinase, causes familial Parkinson's disease (PD). Recent studies have revealed that PINK1 is rapidly degraded in healthy mitochondria but accumulates on the membrane potential (ΔΨm)-deficient mitochondria, where it recruits another familial PD gene product
Transition Metal Complexes of Ethopropazine: Synthesis and Characterization
Debbeti V, et al.
American Journal of Chemistry, 2(6), 294-298 (2012)