H3757
Hyaluronidase from bovine testes
Type VIII, lyophilized powder, 300-1,000 U/mg
Synonym(s):
Hyaluronate 4-glycanohydrolase, Hyaluronoglucosaminidase
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About This Item
CAS Number:
UNSPSC Code:
12352204
NACRES:
NA.54
EC Number:
253-464-3
MDL number:
Specific activity:
300-1,000 U/mg
Biological source:
bovine testis
biological source
bovine testis
Quality Level
conjugate
conjugate (Glucosaminoglycan)
type
Type VIII
form
lyophilized powder
specific activity
300-1,000 U/mg
mol wt
~55 kDa (four subunits of 14 kDa each)
relevant disease(s)
cancer
storage temp.
−20°C
Gene Information
cow ... HYAL1(515397), HYAL2(281838)
Biochem/physiol Actions
Hyaluronidase degrades hyaluronan and has been found to be inappropriately regulated during cancer progression.
These enzymes randomly cleave β-N-acetylhexosamine-[1→4] glycosidic bonds in hyaluronic acid, chondroitin, and chondroitin sulfates.
Preparation Note
Prepared from aseptic filled solution of Type I-S.
Other Notes
One unit will degrade 0.75 μg of the polysaccharide hyaluronic acid per minute at pH 5.35 at 37 ºC (as measured by turbidimetric absorbance (λ: 600nm) when complexed with BSA after 45 minutes).
View more information on enzymes for complex carbohydrate analysis at www.sigma-aldrich.com/enzymeexplorer
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signalword
Danger
hcodes
pcodes
Hazard Classifications
Resp. Sens. 1
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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