M0757
Isopropyl myristate
≥90% (GC)
Synonym(s):
Isopropyl tetradecanoate, Myristic acid isopropyl ester
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About This Item
Linear Formula:
CH3(CH2)12COOCH(CH3)2
CAS Number:
Molecular Weight:
270.45
UNSPSC Code:
12352211
NACRES:
NA.25
PubChem Substance ID:
EC Number:
203-751-4
Beilstein/REAXYS Number:
1781127
MDL number:
form
liquid
InChI key
AXISYYRBXTVTFY-UHFFFAOYSA-N
InChI
1S/C17H34O2/c1-4-5-6-7-8-9-10-11-12-13-14-15-17(18)19-16(2)3/h16H,4-15H2,1-3H3
SMILES string
CCCCCCCCCCCCCC(=O)OC(C)C
biological source
synthetic (organic)
assay
≥90% (GC)
Quality Level
bp
193 °C/20 mmHg (lit.)
mp
~3 °C (lit.)
density
0.85 g/mL at 25 °C (lit.)
functional group
ester
lipid type
saturated FAs
shipped in
ambient
storage temp.
2-8°C
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Related Categories
Application
- Formulation design and development of matrix diffusion controlled transdermal drug delivery of glimepiride.: This study discusses the design of a transdermal drug delivery system for glimepiride, utilizing matrix diffusion mechanisms potentially incorporating Isopropyl Myristate to enhance permeation (Akram et al., 2018).
- Investigation of microemulsion and microemulsion gel formulations for dermal delivery of clotrimazole.: This article evaluates formulations incorporating Isopropyl Myristate for enhanced dermal delivery of clotrimazole, highlighting its role in improving drug solubility and skin absorption rates (Zhang and Michniak-Kohn, 2018).
Biochem/physiol Actions
Isopropyl myristate (myristic acid isopropyl ester) is used to change the physicochemical characteristics of microsheres such as poly(lactic-co-glycolic acid) (PLGA) microspheres. Isopropyl myristate is used as a oil phase component in the formulation of microemulsion systems.
Storage Class
10 - Combustible liquids
wgk
awg
flash_point_f
>302.0 °F
flash_point_c
> 150 °C
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Eva Abramov et al.
Journal of colloid and interface science, 591, 363-372 (2021-02-24)
Modified microemulsions (MEs), termed by us nanodomains (NDs), seem to be suitable vehicles for dermal drug delivery due to their high surface area and the interface enriched with membrane recognizing agents, penetration enhancers, and other components. However, liquid nanodomains do
Mahendra Singh et al.
Journal of controlled release : official journal of the Controlled Release Society, 328, 895-916 (2020-10-19)
The eye is the specialized part of the body and is comprised of numerous physiological ocular barriers that limit the drug absorption at the action site. Regardless of various efforts, efficient topical ophthalmic drug delivery remains unsolved, and thus, it
Ranajay Saha et al.
Langmuir : the ACS journal of surfaces and colloids, 28(22), 8309-8317 (2012-05-11)
An edible microemulsion (ME) composed of Tween 80/butyl lactate/isopropyl myristate (IPM)/water has been formulated. Pseudoternary phase diagram of the system contains a large single isotropic region. The phase behavior of the system is also studied at low pH (2.6) and
T N Engelbrecht et al.
Skin pharmacology and physiology, 25(4), 200-207 (2012-05-23)
In order to elucidate the mode of action of the lipophilic penetration enhancer isopropyl myristate (IPM) on a molecular scale, we investigated oriented quaternary stratum corneum (SC) lipid model membranes based on ceramide AP, cholesterol, palmitic acid and cholesterol sulfate
Fan Yang et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 82(1), 158-163 (2012-06-21)
Transdermal delivery of methotrexate (MTX) was investigated by using the solid-in-oil (S/O) technique. Because MTX was coated with nonionic surfactant molecules, the resulting complex was easy to dissolve in various organic solvents and provided a transparent solution in isopropyl myristate
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