T3165
7-Methoxy-4-(trifluoromethyl)coumarin
≥99% (TLC)
Synonym(s):
Methyl 4-(trifluoromethyl)umbelliferyl ether
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About This Item
Empirical Formula (Hill Notation):
C11H7F3O3
CAS Number:
Molecular Weight:
244.17
UNSPSC Code:
12352204
NACRES:
NA.32
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
225039
Quality Level
assay
≥99% (TLC)
form
powder
solubility
acetone: 50 mg/mL, clear, colorless to faintly yellow
fluorescence
λex 333 nm; λem 416 nm in methanol
SMILES string
COc1ccc2c(OC(=O)C=C2C(F)(F)F)c1
InChI
1S/C11H7F3O3/c1-16-6-2-3-7-8(11(12,13)14)5-10(15)17-9(7)4-6/h2-5H,1H3
InChI key
HAZHUELNIGDYQH-UHFFFAOYSA-N
Application
7-Methoxy-4-(trifluoromethyl)coumarin has been used as a substrate in cytochrome P450 2E1 (CYP2E1) activity assay and aromatase assay.
Biochem/physiol Actions
The enzymatic action of cytochrome P450 2E1 (CYP2E1) on 7-methoxy-4-(trifluoromethyl)coumarin results in a fluorescent product 7-hydroxy-4-(trifluoromethyl)coumarin (HFC) that can be measured at 409/530 nm.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Rebeca Santes-Palacios et al.
Toxicology in vitro : an international journal published in association with BIBRA, 69, 105009-105009 (2020-10-03)
Cytochrome P450 2E1 (CYP2E1) has been proposed as a molecular target in oxidative stress-associated metabolic diseases. Rats are chosen as model organisms in most experiments studying CYP2E1-related toxicity; however, the human relevance of these results remains unclear. To describe differences
Carlo Matera et al.
European journal of pharmacology, 820, 265-273 (2017-12-25)
(±)-3-Methoxy-1-oxa-2,7-diaza-7,10-ethanospiro[4.5]dec-2-ene sesquifumarate (±)-1 was previously characterized as the most selective agonist at α7 neuronal nicotinic acetylcholine receptors in a series of spirocyclic quinuclidinyl-Δ
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1. Little is known about drug metabolism in carnivores. Although the domestic cat (Felis catus) is an obligate carnivore and is the most common companion animal, usage and dosage of many drugs are determined according to information obtained from humans and
Thomas Piper et al.
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The steroid profile, that is, the urinary concentrations and concentration ratios of selected steroids, is used in sports drug testing to detect the misuse of endogenous steroids such as testosterone. Since several years, not only population-based thresholds are applied but
Yuka Ono et al.
Xenobiotica; the fate of foreign compounds in biological systems, 49(6), 627-635 (2018-06-01)
1. Compared to information for herbivores and omnivores, knowledge on xenobiotic metabolism in carnivores is limited. The cytochrome P450 2C (CYP2C) subfamily is recognized as one of the most important CYP groups in human and dog. We identified and characterized
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