333115
2-Isopropylmalic acid
98%
Sinónimos:
2-Hydroxy-2-isopropylsuccinic acid
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Acerca de este artículo
Fórmula lineal:
HO2CCH2C[CH(CH3)2](OH)CO2H
Número CAS:
Peso molecular:
176.17
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
Assay:
98%
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Permítanos ayudarleNombre del producto
2-Isopropylmalic acid, 98%
InChI
1S/C7H12O5/c1-4(2)7(12,6(10)11)3-5(8)9/h4,12H,3H2,1-2H3,(H,8,9)(H,10,11)
SMILES string
CC(C)C(O)(CC(O)=O)C(O)=O
InChI key
BITYXLXUCSKTJS-UHFFFAOYSA-N
assay
98%
mp
144-146 °C (lit.)
functional group
carboxylic acid
hydroxyl
Quality Level
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Categorías relacionadas
Application
2-Isopropylmalic acid was employed as an internal standard in diagnostic model for pancreatic cancer using GC/MS-based human serum metabolomics.
General description
2-Isopropylmalic acid is an intermediate formed during leucine biosynthesis. Budding yeast Saccharomyces cerevisiae secrets 2-isopropylmalic acid and helps in reduction of aluminum toxicity by forming chelate with Al ions, thereby preventing them from entering the cells.
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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P Friden et al.
Molecular and cellular biology, 9(9), 4056-4060 (1989-09-01)
LEU3 of Saccharomyces cerevisiae encodes an 886-amino-acid polypeptide that activates transcription of at least five genes by binding to an upstream decanucleotide sequence. This activation is dependent on the inducer alpha-isopropylmalate, the synthesis of which is repressed by leucine. We
Shozo Tomonaga et al.
Animal science journal = Nihon chikusan Gakkaiho, 89(2), 448-455 (2017-11-21)
Exposure to high ambient temperature is detrimental to the poultry industry. To understand the influence from a metabolic perspective, we investigated the effects of exposure to high ambient temperature on plasma low-molecular-weight metabolite levels in chicks using gas chromatography/mass spectrometry-based
Satoshi Takemoto et al.
Animal science journal = Nihon chikusan Gakkaiho, 88(12), 1970-1978 (2017-07-20)
Long-distance transportation is sometimes inevitable in the beef industry because of the geographic separation of major breeding and fattening areas. Long-distance transportation negatively impacts production and health of cattle, which may, at least partly, result from the disturbance of metabolism
J Y Sze et al.
Science (New York, N.Y.), 258(5085), 1143-1145 (1992-11-13)
In the absence of the leucine biosynthetic precursor alpha-isopropylmalate (alpha-IPM), the yeast LEU3 protein (Leu3p) binds DNA and acts as a transcriptional repressor in an in vitro extract. Addition of alpha-IPM resulted in a dramatic increase in Leu3p-dependent transcription. The
P S Nielsen et al.
Molecular & general genetics : MGG, 264(5), 613-622 (2001-02-24)
Uptake of branched-chain amino acids by Saccharomyces cerevisiae from media containing a preferred nitrogen source is mediated by the permeases encoded by BAP2, BAP3, and VAP1/TAT1. The transcriptional activity of the BAP2 promoter is affected by a number of genes
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