761540
Dibenzocyclooctyne-amine
for Copper-free Click Chemistry
Sinónimos:
DBCO-NH2, DBCO-amine
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Fórmula empírica (notación de Hill):
C18H16N2O
Número CAS:
Peso molecular:
276.33
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352116
MDL number:
Assay:
≥94.5 %
Form:
solid
Servicio técnico
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Permítanos ayudarleQuality Segment
assay
≥94.5 %
form
solid
reaction suitability
reaction type: click chemistry, reagent type: linker
mp
86-96 °C
functional group
amine
storage temp.
−20°C
SMILES string
NCCC(N1CC2=C(C=CC=C2)C#CC3=C1C=CC=C3)=O
InChI
1S/C18H16N2O/c19-12-11-18(21)20-13-16-7-2-1-5-14(16)9-10-15-6-3-4-8-17(15)20/h1-8H,11-13,19H2
InChI key
OCCYFTDHSHTFER-UHFFFAOYSA-N
General description
Dibenzocyclooctyne-amine (DBCO-NH2), is a heterobifunctional linker containing a DBCO moiety commonly used for the site-specific functionalization of nanobodies, enabling the addition of reactive DBCO groups for subsequent click chemistry reactions.
Application
Dibenzocyclooctyne-amine can be used as a :
- Linker to link azide-containing functional groups. It facilitates the formation of linkages through Strain-promoted azide-alkyne cycloaddition reactions (SPAAC)
- Reagent in the synthesis of N-heterocyclic carbene metal thiolates. It functionalizes the metal complexes and increases their reactivity in the strain-promoted alkyne–azide cycloaddition (SPAAC) reactions
- Amine functionalized cyclooctyne derivative. Cyclooctynes are useful in strain-promoted copper-free azide-alkyne cycloaddition reactions. This dibenzocyclooctyne will react with azide functionalized compounds or biomolecules without the need for a Cu(I) catalyst to result in a stable triazole linkage.
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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