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Merck

M-132

N-Metil-N-(trimetilsilil)trifluoroacetamida

ampule of 10 × 1.2 mL, analytical standard, Cerilliant®

Sinónimos:

N-trimetilsilil-N- metil trifluoroacetamida, MSTFA

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Fórmula lineal:
CF3CON(CH3)Si(CH3)3
Número CAS:
24589-78-4
Peso molecular:
199.25
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329817869
EC Number:
246-331-6
Beilstein/REAXYS Number:
1941550
MDL number:
MFCD00000411

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Nombre del producto

N-Metil-N-(trimetilsilil)trifluoroacetamida, ampule of 10 × 1.2 mL, analytical standard, Cerilliant®

InChI key

MSPCIZMDDUQPGJ-UHFFFAOYSA-N

InChI

1S/C6H12F3NOSi/c1-10(12(2,3)4)5(11)6(7,8)9/h1-4H3

SMILES string

CN(C(=O)C(F)(F)F)[Si](C)(C)C

grade

analytical standard

vapor density

>1 (vs air)

vapor pressure

8.8 mmHg ( 27 °C)

reaction suitability

reagent type: derivatization reagent
reaction type: Acylations

packaging

ampule of 10 × 1.2 mL

manufacturer/tradename

Cerilliant®

technique(s)

gas chromatography (GC): suitable

refractive index

n20/D 1.38 (lit.)

bp

130-132 °C (lit.)

density

1.075 g/mL at 25 °C (lit.)

application(s)

forensics and toxicology

format

neat

storage temp.

−20°C

Quality Level

100

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Application

MSTFA reagent may be used as a derivatizing agent in the following:
  • Analysis of estrogen steroids such as estrone (E1), 17α-ethinylestradiol (EE2), and trenbolone acetate metabolites, melengestrol in environmental matrices using gas chromatography coupled to mass spectrometry (GC-MS).
  • Quantification of ibuprofen, naproxen, ketoprofen, and diclofenac in wastewater samples using gas chromatography coupled to mass spectrometry (GC-MS).

Features and Benefits

  • Very volatile of TMS-acetamides.
  • More volatile than BSA or BSTFA but with similar silylation strength.
  • Useful in the analysis of volatile trace materials.
  • Used in the preparation of volatile and thermally stable derivatives for GC and MS analysis.

General description

MSTFA (N-Methyl-N-trimethylsilylfluoroacetamide) is an important trimethylsilyl reagent, and a commonly applied reagent since it is highly reactive towards a broad range of compound classes. GC-MS optimization studies reveal the use of this reagent either alone or in combination with 1% of trimethylchlorosilane as a catalyst for silylation of complex mixtures. It has similar reactivity as BSA and BSTFA.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Clase de almacenamiento

3 - Flammable liquids

wgk

WGK 3

flash_point_f

78.8 °F - closed cup

flash_point_c

26 °C - closed cup

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Certificados de análisis (COA)

Lot/Batch Number

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Identification and quantification of ibuprofen, naproxen, ketoprofen and diclofenac present in waste-waters, as their trimethylsilyl derivatives, by gas chromatography mass spectrometry
Sebok A, et al.
Talanta, 76(3), 642-650 (2008)
The use of trimethylsilyl cyanide derivatization for robust and broad-spectrum high-throughput gas chromatography?mass spectrometry based metabolomics
Khakimov B, et al.
Analytical and Bioanalytical Chemistry, 405(3), 9193-9205 (2013)
Analysis of trenbolone acetate metabolites and melengestrol in environmental matrices using gas chromatography--tandem mass spectrometry
Parker AJ, et al.
Talanta, 99(3), 238-246 (2012)
Stina K Lien et al.
Journal of chromatography. A, 1247, 118-124 (2012-06-15)
GC-MS analysis of silylated metabolites is a sensitive method that covers important metabolite groups such as sugars, amino acids and non-amino organic acids, and it has become one of the most important analytical methods for exploring the metabolome. Absolute quantitative
Guro Forsdahl et al.
Journal of separation science, 27(1-2), 110-114 (2004-09-01)
A sensitive method for the quantification of free salbutamol in human urine is described. Sample clean up is performed using SPE on a mixed phase extraction column. Derivatisation is performed with N-methyl-N-trimethylsilyltrifluoroacetamide (MSTFA) and the extract is analysed by GC-MS.
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