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475951

A22 hydrochloride

Name: A22 hydrochloride
Brand: MM

≥95% (HPLC),cell-permeable isothiourea compound, solid

Sinónimos:

MreB Perturbing Compound A22, S-(3,4-Dichlorobenzyl)isothiourea, HCl

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Fórmula empírica (notación de Hill):

C₈H₈Cl₂N₂S · xHCl

Número CAS:

22816-60-0

Peso molecular:

235.13 (free base basis)

UNSPSC Code:

51111800

NACRES:

NA.77

MDL number:

MFCD00035050

Assay:

≥95% (HPLC)

Form:

solid

Storage condition:

OK to freeze, desiccated (hygroscopic), protect from light

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Propiedades

Nombre del producto

MreB Perturbing Compound A22, A cell-permeable isothiourea compound that specifically, rapidly and reversibly perturbs MreB function without affecting eukaryotic actin polymerization.

Quality Segment

100

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

color

white

solubility

water: 2 mg/mL, DMSO: 200 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

S(Cc1cc(c(cc1)Cl)Cl)\C(=N\[H])\N.Cl

InChI

1S/C8H8Cl2N2S.ClH/c9-6-2-1-5(3-7(6)10)4-13-8(11)12;/h1-3H,4H2,(H3,11,12);1H

InChI key

VBJNMXMOMSWRDV-UHFFFAOYSA-N

Descripción

General description

A cell-permeable isothiourea compound that specifically, rapidly and reversibly perturbs MreB function without affecting eukaryotic actin polymerization. Reported to affect the growth and morphology of Caulobacter crescentus, convert rod-shaped E. coli to round cells, and block DNA segregation without affecting DNA replication. Suggested to interact with MreB′s nucleotide binding pocket and is useful for the temporal analysis of MreB function.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
MreB

Product does not compete with ATP.

Reversible: yes

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution in DMSO, aliquot and freeze (-20°C. DMSO stock solutions are stable for up to 1 month at -20°C. Reconstitute in H₂O just prior to use; aqueous stock solutions are stable for up to 12 hr. Stable for up to 2 days in acidic medium.

Other Notes

Gitai, Z., et al. 2005. Cell120, 329.
Jensen, R.B., et al. 2002. Nat. Rev. Mol. Cell Biol.3, 167.
Iwai, N., et al. 2002. Biosci. Biotechnol. Biochem.66, 2658.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Clase de almacenamiento

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c