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487928

Nocodazole

Name: Nocodazole
Brand: MM

≥99% (HPLC), solid, microtuble inhibitor, Calbiochem

Sinónimos:

Nocodazole, R17934, Methyl-[5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]-carbamate

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Fórmula empírica (notación de Hill):

C₁₄H₁₁N₃O₃S

Número CAS:

31430-18-9

Peso molecular:

301.32

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD00005588

Assay:

≥99% (HPLC)

Form:

solid

Storage condition:

OK to freeze

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Propiedades

Nombre del producto

Nocodazole, Inhibitor of mitosis.

Quality Segment

100

description

RTECS - DD6521000

assay

≥99% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

color

pale yellow

solubility

DMSO: 5 mg/mL

shipped in

ambient

storage temp.

10-30°C

SMILES string

[s]1c(ccc1)C(=O)c2cc3nc([nH]c3cc2)NC(=O)OC

InChI

1S/C14H11N3O3S/c1-20-14(19)17-13-15-9-5-4-8(7-10(9)16-13)12(18)11-3-2-6-21-11/h2-7H,1H3,(H2,15,16,17,19)

InChI key

KYRVNWMVYQXFEU-UHFFFAOYSA-N

Descripción

General description

Inhibitor of mitosis. Has highly specific antimicrotubular activity for mammalian cells in culture. Promotes tubulin depolymerization. Also available as a 50 mM solution in DMSO (Cat. No. 487929).

Biochem/physiol Actions

Cell permeable: no

Primary Target
Promotes tubulin depolymerization

Product does not compete with ATP.

Reversible: no

Preparation Note

Following reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 1 year at -20°C.

Other Notes

Park, H., et al. 2011. Chem. Med. Chem.in press.
Bunz, F., et al. 1998. Science 282, 1497.
Fleischman, L.F., et al. 1993. Oncogene8, 771.
Pomies, P., and Block, M.R. 1992. Biochem. Biophys. Res. Commun.189, 1429.
Rennison, M.E., et al. 1992. J. Cell Sci. 102, 239.
Thyberg, J., and Moskalewski, S. 1992. J. Cell Sci.103, 1167.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Carcinogenic / Teratogenic (D)

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pictograms

GHS08

signalword

Warning

hcodes

H341,H361d

pcodes

P201 - P202 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Muta. 2 - Repr. 2

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c