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HCD8MAG-15K

MILLIPLEX® Human CD8+ T Cell Panel

Configurable Human CD8+ T Cell 17-Plex Panel

Sinónimos:

Human CD8 T cell cytokine panel, Human cytokine multiplex kit, Luminex® human cytokine immunoassay, Millipore human cytokine panel

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UNSPSC Code:
12161503
NACRES:
NA.84
eCl@ss:
32161000

Nombre del producto

MILLIPLEX® Human CD8+ T Cell Panel,

Quality Segment

200

description

Configurable Human CD8+ T Cell 17-Plex Panel

species reactivity

human

packaging

pkg of 1 ea

manufacturer/tradename

Milliplex®

assay range

standard curve range: 0.4-1,500 pg/mL
(IL-6), standard curve range: 0.5-2,000 pg/mL
(TNFα), standard curve range: 1-3,500 pg/mL
(MIP-1α), standard curve range: 1-5,000 pg/mL
(Granzyme B), standard curve range: 1-5,000 pg/mL
(IFNγ), standard curve range: 1-5,000 pg/mL
(IL-5), standard curve range: 10-50,000 pg/mL
(Perforin), standard curve range: 10-50,000 pg/mL
(sFasL), standard curve range: 2-10,000 pg/mL
(IL-4), standard curve range: 2-10,000 pg/mL
(sCD137), standard curve range: 2-7,500 pg/mL
(IL-13), standard curve range: 2-7,500 pg/mL
(IL-2), standard curve range: 20-100,000 pg/mL
(Granzyme A), standard curve range: 4-15,000 pg/mL
(GM-CSF), standard curve range: 400-1,650,000 pg/mL
(sFas), standard curve range: 5-20,000 pg/mL
(IL-10), standard curve range: 7-30,000 pg/mL
(MIP-1β)

technique(s)

multiplexing: suitable

input

cell culture supernatant(s)
plasma

detection method

fluorometric (Luminex® xMAP® technology)

shipped in

wet ice

storage temp.

2-8°C

General description

CD8+ T cells (also known as cytotoxic T cells, cytolytic T cells and killer T cells) belong to a sub-group of T cells capable of inducing the death of infected somatic or tumor cells. T cells that bind weakly to Major Histocompatibility Complex (MHC) self-antigens are positively selected into single-positive CD4+ or CD8+ T cells in the thymus. Those CD8+ T cells that survive and mature after activation become cytotoxic cells, expressing T-cell receptors (TCRs) capable of recognizing specific antigenic peptides bound to Class I MHC molecules and the glycoprotein CD8. Affinity between the CD8 protein and the MHC molecule helps to keep the cytotoxic T cell and target closely bound during antigen specific activation. Once activated, CD8+ T cells are generally classified as having a predefined cytotoxic role within the immune system and undergo IL-2 induced clonal expansion, which increases the number of cells specific for the target antigen. The CD8+ T cells then travel throughout the body in search of antigen-positive somatic/tumor cells.

Application

MILLIPLEX® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze up to 17 analytes in human serum, plasma, and cell culture supernatants.

Analytes included: GM-CSF, sCD137, IFNγ, sFas, sFasL, Granzyme A, Granzyme B, IL-2, IL-4, IL-5, IL-6, IL-10, IL-13, MIP-1α, MIP-1β, TNF-α, Perforin

Assay Characteristics: Refer to kit protocol for assay cross-reactivity, sensitivity, precision, and accuracy.

Features and Benefits

  • Enhanced Understanding of Immune Response: The ability to measure multiple cytokines and chemokines associated with CD8+ T cell activity aids researchers in understanding the immune response in various conditions, including infections and cancers. Streamlined.
  • Research Process: The overnight run time and simple sample preparation facilitate a more efficient research workflow, allowing for quicker data analysis and decision-making.
  • Configurable Options for Diverse Research Needs: The ability to configure the panel ensures that researchers can adapt the kit to their specific study requirements, making it a versatile tool in immunology research.
  • Conservation of Valuable Samples: By quantifying multiple analytes from a single sample, researchers can conserve precious sample volume, which is especially important in studies involving limited or difficult-to-obtain samples.
  • Comprehensive Analyte Detection: The panel includes 15 key analytes relevant to CD8+ T cell function and activity, such as GM-CSF, IFNγ, IL-2, Granzyme A, and Perforin, allowing for a detailed immune response analysis.

Legal Information

Luminex is a registered trademark of Luminex Corporation
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

Disclaimer

For research use only. Not for use in diagnostic procedures.

Label License/Sticker for Assay Product:

By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.

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Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2

target_organs

Respiratory Tract

Clase de almacenamiento

10 - Combustible liquids

wgk

WGK 3

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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