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Merck

PHR1016

Chlorpheniramine Maleate

Pharmaceutical Secondary Standard; Certified Reference Material

Sinónimos:

(±)-Chlorpheniramine maleate salt

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Fórmula empírica (notación de Hill):
C16H19ClN2 · C4H4O4
Número CAS:
113-92-8
Peso molecular:
390.86
NACRES:
NA.24
PubChem Substance ID:
329823047
UNSPSC Code:
41116107
EC Number:
204-037-5
MDL number:
MFCD00069225

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InChI key

DBAKFASWICGISY-BTJKTKAUSA-N

InChI

1S/C16H19ClN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

SMILES string

CN(C)CCC(C1=CC=C(Cl)C=C1)C2=NC=CC=C2.O=C(/C=C\C(O)=O)O

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. C1800000, traceable to USP 1123000

API family

chlorpheniramine

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

mp

130-135 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

Gene Information

human ... HRH1(3269)

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Chlorpheniramine Maleate is an H1-receptor antagonist drug grouped under the class of antihistaminic compounds.

Application

Chlorpheniramine Maleate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

H1 Histamine receptor antagonist.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC0771 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Clase de almacenamiento

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Normal-phase LC method for simultaneous analysis of pseudophedrine hydrochloride, dextromethorphan hydrobromide, chlorpheniramine maleate, and paracetamol in tablet formulations
Al-Rimawi F
Saudi Pharmaceutical Journal : SPJ : The Official Publication of the Saudi Pharmaceutical Society, 18(2), 103-106 (2010)
Poly (ethyleneglycol) column for the determination of acetaminophen, phenylephrine and chlorpheniramine in pharmaceutical formulations
Garcia A, et al.
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 785(2), 237-243 (2003)
New approaches with two cyano columns to the separation of acetaminophen, phenylephrine, chlorpheniramine and related compounds
Olmo B, et al.
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 817(2), 159-165 (2005)
CE versus HPLC for the dissolution test in a pharmaceutical formulation containing acetaminophen, phenylephrine and chlorpheniramine
Marin A and Barbas C
Journal of Pharmaceutical and Biomedical Analysis, 35(4), 769-777 (2004)
Validation of a HPLC quantification of acetaminophen, phenylephrine and chlorpheniramine in pharmaceutical formulations: capsules and sachets.
Marin A, et al.
Journal of Pharmaceutical and Biomedical Analysis, 29(4), 701-714 (2002)
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