PHR1148
4-Aminophenol
Pharmaceutical Secondary Standard; Certified Reference Material
Sinónimos:
4-Aminophenol, 4-Hydroxyaniline
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Fórmula lineal:
H2NC6H4OH
Número CAS:
Peso molecular:
109.13
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
204-616-2
Beilstein/REAXYS Number:
385836
MDL number:
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Permítanos ayudarleInChI key
PLIKAWJENQZMHA-UHFFFAOYSA-N
InChI
1S/C6H7NO/c7-5-1-3-6(8)4-2-5/h1-4,8H,7H2
SMILES string
Nc1ccc(O)cc1
grade
certified reference material, pharmaceutical secondary standard
agency
traceable to Ph. Eur. Y0001955, traceable to USP 1021204
API family
mesalazine, paracetamol, acetaminophen
CofA
current certificate can be downloaded
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
Quality Level
mp
185-189 °C (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-30°C
General description
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
It is a primary degradation product of the widely used antipyretic and analgesic drug acetaminophen, also known as paracetamol, formed on its hydrolysis.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
It is a primary degradation product of the widely used antipyretic and analgesic drug acetaminophen, also known as paracetamol, formed on its hydrolysis.
Application
This pharmaceutical secondary standard can also be used as follows:
- Separation and estimation of acetaminophen and its process impurities in commercial acetaminophen tablets using high-performance liquid chromatography (HPLC)
- Simultaneous electrochemical determination of acetaminophen and its impurity K using a reduced graphene oxide-titanium nitride (RGO-TiN) nanohybrid
- Development and validation of HPLC-based stability indicating method for the determination of acetaminophen, chlorpheniramine maleate, and their possible degradation products in an over-the-counter syrup formulation
- Determination of acetaminophen, pamabrom, and their impurities using high-performance thin layer chromatography (HPTLC) and reversed phase-high performance liquid chromatography (RP-HPLC), according to the ICH guidelines, in their combined dosage tablets
- Combined analysis of acetaminophen, chlorzoxazone, and their major degradation impurities using thin-layer chromatographic (TLC)-densitometric method in their combined dosage capsules
Analysis Note
These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.
Other Notes
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
To see an example of a Certificate of Analysis for this material enter LRAC3043 in the slot below. This is an example certificate only and may not be the lot that you receive.
signalword
Warning
Hazard Classifications
Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Muta. 2 - Skin Sens. 1 - STOT RE 2
target_organs
Kidney
Clase de almacenamiento
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Simultaneous Estimation of Acetaminophen, Chlorpheniramine Maleate, Methyl Paraben, Propyl Paraben, Sodium Benzoate and Related Impurities in Over-the-Counter Syrup Formulation
Palakurthi AK and Dongala T
Pharmaceutical Chemistry Journal, 1-7 (2022)
Facile green synthesis of graphene-titanium nitride hybrid nanostructure for the simultaneous determination of acetaminophen and 4-aminophenol
Kong F-Y, et al.
Sensors and Actuators B, Chemical, 213, 397-403 (2015)
Y Xu et al.
Clinical chemistry, 36(11), 1941-1944 (1990-11-01)
A sandwich-type heterogeneous enzyme immunoassay with flow-injection analysis for alpha-fetoprotein (AFP) in human serum has been developed. 4-Aminophenol, the product of enzymatic reaction, is detected amperometrically. The interassay CV for this electrochemical enzyme immunoassay was less than 8.2%, with a
Abilash Gangula et al.
Langmuir : the ACS journal of surfaces and colloids, 27(24), 15268-15274 (2011-10-27)
A simple, green method is described for the synthesis of Gold (Au) and Silver (Ag) nanoparticles (NPs) from the stem extract of Breynia rhamnoides. Unlike other biological methods for NP synthesis, the uniqueness of our method lies in its fast
Raquel Obregon et al.
Talanta, 94, 30-35 (2012-05-23)
A Pt layer/Pt disk electrode configuration was used as a scanning electrochemical microscopy (SECM) probe. The glass seal part of the insulator was covered with a Pt layer to form an exposed pseudo reference electrode. In a HEPES-based medium at
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