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Merck

455180

Cloruro de hidrógeno solution

2.0 M in diethyl ether

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Fórmula empírica (notación de Hill):
HCl
Número CAS:
Peso molecular:
36.46
NACRES:
NA.21
PubChem Substance ID:
UNSPSC Code:
12352301
MDL number:
Concentration:
1.90-2.20 M (with NaOH, titration), 2.0 M in diethyl ether
Form:
liquid
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form

liquid

Quality Level

concentration

1.90-2.20 M (with NaOH, titration), 2.0 M in diethyl ether

bp

34.6 °C

density

0.747 g/mL at 25 °C

storage temp.

2-8°C

SMILES string

Cl

InChI

1S/ClH/h1H

InChI key

VEXZGXHMUGYJMC-UHFFFAOYSA-N

General description

Hydrogen chloride solution contains 2M hydrogen chloride in diethyl ether as the solvent. It is a strong acid and highly corrosive in nature and is commonly used in the selective cleavage of the protecting groups 2,4,6-trimethoxyphenyl from the respective (2,4,6-trimethoxyphenyl)silane to produce chlorosilanes.

Application

Hydrogen chloride solution can be used as a reagent to synthesize:
  • Cyanohydrin alkyl ethers via chiral Bronsted acid-mediated hydrocyanation of vinyl ethers with silyl cyanides.
  • N, N-Dimethylaniline hydrochloride salts via Pd-catalyzed Buchwald-Hartwig amination of aryl triflates with dimethylamines.
It can also be used as a catalyst for the amidation of carboxylic acids with amines to synthesize amides.


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signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Flam. Liq. 1 - Met. Corr. 1 - STOT SE 3

target_organs

Central nervous system

supp_hazards

Clase de almacenamiento

3 - Flammable liquids

wgk

WGK 1

flash_point_f

-29.2 °F - closed cup

flash_point_c

-34 °C - closed cup



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An automated SPE-based high-yield synthesis of [11C] acetate and [11C] palmitate: no liquid-liquid extraction, solvent evaporation or distillation required.
Mock BH, et al.
Nuclear Medicine and Biology, 38(8), 1135-1142 (2011)
Corrosion behavior of mild steel in hydrochloric acid solutions
Ehteram N A, et al.
International Journal of Electrochemical Science, 806-818 (2008)
The 2, 4, 6-trimethoxyphenyl unit as a unique protecting group for silicon in synthesis and the silylation potential of (2, 4, 6-trimethoxyphenyl) silanes
Friedrich P, et al.
Organometallics, 26, 6014-6028 (2007)