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Merck

62320

(±)-α-Lipoic acid

≥98.0% (HPLC), solid

Sinónimos:

(±)-1,2-Dithiolane-3-pentanoic acid, 6,8-Dithiooctanoic acid, DL-α-Lipoic acid, DL-6,8-Thioctic acid, Lip(S2)

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Fórmula empírica (notación de Hill):
C8H14O2S2
Número CAS:
1077-28-7
Peso molecular:
206.33
UNSPSC Code:
12352100
PubChem Substance ID:
57651855
NACRES:
NA.21
EC Number:
214-071-2
MDL number:
MFCD00005474
Beilstein/REAXYS Number:
81853
Assay:
≥98.0% (HPLC), ≥98.0%
Form:
solid

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Nombre del producto

(±)-α-Lipoic acid, ≥98.0%

Quality Level

200

assay

≥98.0% (HPLC), ≥98.0%

form

solid

ign. residue

≤0.1%

loss

≤0.2% loss on drying

bp

>286 °C/1.013 hPa

mp

60-62 °C

solubility

water: 0.87 g/L at 22 °C

density

1.4 g/cm3 at 23 °C

functional group

carboxylic acid, disulfide

storage temp.

2-8°C

SMILES string

[OC(=O)CCCCC1CCSS1], OC(=O)CCCCC1CCSS1

InChI

[1S/C8H14O2S2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H,9,10)], 1S/C8H14O2S2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H,9,10)

InChI key

[AGBQKNBQESQNJD-UHFFFAOYSA-N], AGBQKNBQESQNJD-UHFFFAOYSA-N

Gene Information

human ... ACHE(43), BCHE(590)
rat ... Adra1a(29412), Adra1b(24173), Adra1d(29413)

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General description

α-lipoic acid (ALA, thioctic acid) is a natural organosulfur compound produced in plants, animals and humans. It is a powerful antioxidant and plays a role in the forming nucleic acids, building blocks of DNA.

This product is a racemic mixture.

Application

(±)-α-Lipoic acid has been used:

  • In in vitro lipoylation studies and in the pyruvate dehydrogenase complex (PDC)-pyruvate dehydrogenase kinase (PDHK) functional assay.
  • To investigate its antioxidative effect on developing cerebellum of rats exposed to arsenic during postnatal period.

Biochem/physiol Actions

Antioxidant and coenzyme needed for the activity of enzyme complexes such as pyruvate dehydrogenase and glycine decarboxylase.
Antioxidant and coenzyme needed for the activity of enzyme complexes such as those of pyruvate dehydrogenase and glycine decarboxylase. Exogenous thioctic acid is reduced intracellularly by two or more enzymes. The reduced form then influences a number of cell processes by direct radical scavenging, recycling of other antioxidants, increasing glutathione synthesis, and modulating transcription factor activity particularly that of NF-κB. Decreases the phagocytosis of myelin by macrophages.
(±)-α-Lipoic acid exhibits direct free radical scavenging property and reduces the increased oxidative stress. In addition, it might also exhibit prooxidant activity. α-Lipoic acid functions as an important prosthetic group in α-keto acid dehydrogenase complexes of the mitochondria. It acts as a potential therapeutic for diabetic patients with distal symmetric polyneuropathy (DSP). α-Lipoic acid is also used in the treatment of energy-impaired and redox unbalanced diseases.

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

pictograms

Exclamation markEnvironment
GHS07,GHS09

signalword

Warning

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Certificados de análisis (COA)

Lot/Batch Number
WXBF8325V
WXBF7281V
WXBF6450V
WXBF5862V
WXBF5783V

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Insights on the Use of ?-Lipoic Acid for Therapeutic Purposes
Salehi B., et. al.
Biomolecules, 9(8), 356-356 (2019)
M. Koike et al.
Antibiotics, Vitamins and Hormones, 112-112 (1977)
Component co-expression and purification of recombinant human pyruvate dehydrogenase complex from baculovirus infected SF9 cells
Jiang Y, et al.
Protein Expression and Purification, 97, 9-16 (2014)
Ameliorative role of antioxidant supplementation on sodium-arsenite induced adverse effects on the developing rat cerebellum
Kaushal P, et al.
Journal of Ayurveda and integrative medicine (2019)
Catherine Grogan et al.
Sensors (Basel, Switzerland), 20(3) (2020-02-12)
The high sensitivity of silicon microcantilever sensors has expanded their use in areas ranging from gas sensing to bio-medical applications. Photochromic molecules also represent promising candidates for a large variety of sensing applications. In this work, the operating principles of
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