A0752

Adenosine 5′-diphosphoribose sodium salt

Name: Adenosine 5′-diphosphoribose sodium salt
Brand: SIGMA

≥93%, from yeast (candida utilis), powder

Sinónimos:

ADPR, ADP-Ribose

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About This Item

Fórmula empírica (notación de Hill):

C₁₅H₂₃N₅O₁₄P₂

Número CAS:

68414-18-6

Peso molecular:

559.32

UNSPSC Code:

41106305

PubChem Substance ID:

24890449

NACRES:

NA.51

MDL number:

MFCD00136017

Nombre del producto

Adenosine 5′-diphosphoribose sodium salt, ≥93%

SMILES string

[Na].Nc1ncnc2n(cnc12)C3OC(COP(O)(=O)OP(O)(=O)OCC(O)C(O)C(O)C=O)C(O)C3O

InChI

1S/C15H23N5O14P2.Na.H/c16-13-9-14(18-4-17-13)20(5-19-9)15-12(26)11(25)8(33-15)3-32-36(29,30)34-35(27,28)31-2-7(23)10(24)6(22)1-21;;/h1,4-8,10-12,15,22-26H,2-3H2,(H,27,28)(H,29,30)(H2,16,17,18);;

InChI key

NWPVXDZLQTURKI-UHFFFAOYSA-N

biological source

yeast (candida utilis)

assay

≥93%

form

powder

solubility

water: 50 mg/mL, clear, colorless

storage temp.

−20°C

Quality Level

200

Categorías relacionadas

Biochemicals

Nucleosides and Nucleotides

Application

5′-Deoxy-5′-(methylthio)adenosine has been used:

to give a range of nicotinamide adenine dinucleotide (NADH)
oxidation rates for the respiratory complex (CI/CIII/CIV)
CI/alternative(AOX) pathway
to measure poly(ADP-ribose) glycohydrolaseactivity
poly(ADP-ribose) (PAR) binding competition assay
oxidase (AOX) pathway
to measure poly(ADP-ribose) glycohydrolase activity
poly(ADP-ribose) (PAR) binding competition assay

Biochem/physiol Actions

Adenosine5′-diphosphoribose (ADP-Ribose) is used as the basic building block used as a substrate in the formation of poly(ADP-ribose) by members of the poly(ADP-ribose) polymerase (PARP) family. Poly(ADP-ribose) formation and degradation are important components of DNA repair and apoptosis signaling. ADP-Ribose initiates the transient receptor potential subfamily melastatin, type2 (TRPM2), a Na⁺, Ca2⁺, and K⁺ cation channel.

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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