B107
L-BMAA hydrochloride
≥97% (NMR), neurotoxin, powder
Sinónimos:
S(+)-2-Amino-3-(methylamino)propionic acid hydrochloride
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Fórmula empírica (notación de Hill):
C4H10N2O2 · HCl
Número CAS:
Peso molecular:
154.60
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.32
MDL number:
Servicio técnico
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Permítanos ayudarleNombre del producto
L-BMAA hydrochloride, ≥97% (NMR), powder
Quality Level
assay
≥97% (NMR)
form
powder
optical activity
[α]/D +21 to +31°, c = 0.5 M in 0.1 M HCl(lit.)
storage condition
desiccated
color
white to beige
solubility
H2O: soluble (solutions may be stored for several days at 4 °C)
storage temp.
−20°C
SMILES string
Cl.CNC[C@H](N)C(O)=O
InChI
1S/C4H10N2O2.ClH/c1-6-2-3(5)4(7)8;/h3,6H,2,5H2,1H3,(H,7,8);1H/t3-;/m0./s1
InChI key
VDXYGASOGLSIDM-DFWYDOINSA-N
General description
L-BMAA hydrochloride/β-N-methylamino-l-alanine (BMAA) is a cyanobacterial neurotoxin.
Application
L-BMAA hydrochloride has been used as a standard to compare all the samples in the analysis of β-N-methylamino-l-alanine (BMAA) isomers in desert crust material. It has also been used as an additive with f/2+Si medium to treat the cells of Phaeodactylum tricornutum and Thalassiosira weissflogii to study its effect on them.
Biochem/physiol Actions
L-BMAA hydrochloride helps to block the addition of heparan sulfate to glypican-1. It possesses unusual glutamate receptor binding properties. It may cause amyotrophic lateral sclerosis/Lou Gehrig′s disease.
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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The cyanobacterial neurotoxin beta-N-methylamino-l-alanine prevents addition of heparan sulfate to glypican-1 and increases processing of amyloid precursor protein in dividing neuronal cells
Cheng F, et al.
Experimental Cell Research (2019)
Aifeng Li et al.
Aquatic toxicology (Amsterdam, Netherlands), 221, 105425-105425 (2020-02-15)
Neurotoxin β-N-methylamino-L-alanine (BMAA) has been widely detected in diverse aquatic organisms and hypothesized as an environmental risk to neurodegenerative diseases in humans. However, the knowledge of its toxicity to marine organisms requires attention. In the present study, embryos and sperm
Alexandra Lepoutre et al.
Toxins, 12(2) (2020-01-25)
The environmental neurotoxin β-methylamino-l-alanine (BMAA) may represent a risk for human health. BMAA accumulates in freshwater and marine organisms consumed by humans. However, few data are available about the kinetics of BMAA accumulation and detoxification in exposed organisms, as well