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H1512

Haloperidol

Name: Haloperidol
Brand: SIGMA

≥98% (TLC), powder, dopamine receptor antagonist

Sinónimos:

4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone, 4-[4-(4-Chlorophenyl)-4-hydroxypiperidino]-4′-fluorobutyrophenone, 4-[4-(p-Chlorophenyl)-4-hydroxypiperidino]-4′-fluorobutyrophenone

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Fórmula empírica (notación de Hill):

C₂₁H₂₃ClFNO₂

Número CAS:

52-86-8

Peso molecular:

375.86

NACRES:

NA.77

PubChem Substance ID:

24277917

UNSPSC Code:

12352200

EC Number:

200-155-6

MDL number:

MFCD00051423

Form:

powder

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Propiedades

Nombre del producto

Haloperidol, powder

form

powder

color

white

solubility

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.39 mg/mL, 0.1 M HCl: 3 mg/mL, DMSO: soluble, H₂O: insoluble, ethanol: soluble

originator

Johnson & Johnson

SMILES string

OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c3ccc(Cl)cc3

InChI

1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2

InChI key

LNEPOXFFQSENCJ-UHFFFAOYSA-N

Gene Information

Descripción

Application

Haloperidol has been used:

in ethanol to serves as an inhibitor of Erg2p
to address the mechanism of haloperidol in ferroptosis using hepatocellular carcinoma cells: Hep G2 and Huh-7 cell lines
in receptor internalization assay
as an antipsychotic drug in Dulbecco′s Modified Eagle medium

Biochem/physiol Actions

Haloperidol is a butyrophenone antipsychotic. It is also classified as a neuroleptic (powerful tranquilizer). Haloperidol acts as a D2, D3, and D4 dopamine receptor antagonist and thus causes Parkinson′s disorder. It also has a negative effect on the central nervous system.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.