M6191
GW9662
>98% (HPLC), PPARγ antagonist, powder
Sinónimos:
2-Chloro-5-nitro-N-phenylbenzamide
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Fórmula empírica (notación de Hill):
C13H9ClN2O3
Número CAS:
Peso molecular:
276.68
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
>98% (HPLC)
Form:
powder
Servicio técnico
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Permítanos ayudarleNombre del producto
GW9662, >98% (HPLC)
assay
>98% (HPLC)
form
powder
color
white
solubility
DMSO: 26 mg/mL, H2O: insoluble
storage temp.
2-8°C
SMILES string
[O-][N+](=O)c1ccc(Cl)c(c1)C(=O)Nc2ccccc2
InChI
1S/C13H9ClN2O3/c14-12-7-6-10(16(18)19)8-11(12)13(17)15-9-4-2-1-3-5-9/h1-8H,(H,15,17)
InChI key
DNTSIBUQMRRYIU-UHFFFAOYSA-N
Gene Information
human ... PPARG(5468)
Application
GW9662 has been used as a peroxisome proliferator activated receptor γ (PPARγ) antagonist in human pluripotent stem cells, in phenylephrine stimulated cardiomyocytes and to inhibit the protective effect of telmisartan pheochromocytoma, PC12 cells.
Biochem/physiol Actions
GW9662 is an irreversible PPARγ antagonist. GW9662 inhibits connective tissue growth factor and activation of CD36 by IL-4.
GW9662 is an irreversible PPARγ antagonist; inhibits connective tissue growth factor, and activation of CD36 by IL-4.
GW9662 (2-chloro-5-nitrobenzanilide) binds to the ligand binding site of the peroxisome proliferator activated receptor γ (PPARγ) and results in the inhibition of adipocyte differentiation. It favors cell growth suppression in breast cancer cell lines even in the presence of PPARγ agonist rosiglitazone. It stimulates M2c macrophages differentiation and triggers growth arrest-specific 6 (Gas6) expression. GW9662 co treatment with other PPARγ ligands elicits antiproliferative effects on the glioblastoma stem cells and could be a potent therapeutic agent.
Features and Benefits
This compound is featured on the Nuclear Receptors (PPARs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Legal Information
Sold for research purposes only, under agreement from GlaxoSmithKline
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
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