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PZ0005

Voriconazole

Name: Voriconazole
Brand: SIGMA

≥98% (HPLC), powder, ergosterol synthesis inhibitor

Sinónimos:

2R,3S-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol, UK-109496

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Fórmula empírica (notación de Hill):

C₁₆H₁₄F₃N₅O

Número CAS:

137234-62-9

Peso molecular:

349.31

UNSPSC Code:

12352200

PubChem Substance ID:

329823674

NACRES:

NA.77

MDL number:

MFCD00905717

Assay:

≥98% (HPLC)

Form:

powder

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Propiedades

Nombre del producto

Voriconazole, ≥98% (HPLC)

Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white

solubility

DMSO: >20 mg/mL

storage temp.

room temp

SMILES string

C[C@@H](c1ncncc1F)[C@](O)(Cn2cncn2)c3ccc(F)cc3F

InChI

1S/C16H14F3N5O/c1-10(15-14(19)5-20-7-22-15)16(25,6-24-9-21-8-23-24)12-3-2-11(17)4-13(12)18/h2-5,7-10,25H,6H2,1H3/t10-,16+/m0/s1

InChI key

BCEHBSKCWLPMDN-MGPLVRAMSA-N

Descripción

General description

Voriconazole is a triazole and a synthetic derivative of fluconazole.

Application

Voriconazole has been used:

as a control and Erg11 inhibitor in YPD medium
as a reference drug to test the activity of essential oils against clinical strains of Candida sp.
as an antifungal agent to test its interactions with valproic acid (VPA)
to compare its in vitro antifungal activity with essential oils and its components against Cryptococcus neoformans azole-susceptible and not-susceptible clinical isolates

Biochem/physiol Actions

Voriconazole is an antifungal used to treat serious fungal infections. Voriconazole inhibits ergosterol synthesis by inhibiting CYP450-dependent 14-α sterol demethylase resulting in a depletion of ergosterol in fungal cell membranes.

Voriconazole is an antifungal, which inhibits ergosterol synthesis.

Voriconazole is used to treat invasive aspergillosis (IA). It is vigorous against Candida species, including the strains of Candida albicans, which shows resistance to fluconazole.

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pictograms

GHS06,GHS08

signalword

Danger

hcodes

H301,H341,H351,H361,H371,H372,H373,H412

pcodes

P202 - P260 - P264 - P273 - P280 - P301 + P310

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Chronic 3 - Carc. 2 - Muta. 2 - Repr. 2 - STOT RE 1 - STOT RE 2 Oral - STOT SE 2 Oral

target_organs

Eyes, Liver,Kidney

Clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

flash_point_f

Not applicable

flash_point_c