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SML0362

NPS2143 hydrochloride

Name: NPS2143 hydrochloride
Brand: SIGMA

≥98% (HPLC), Calcium-sensing receptor antagonist, powder

Sinónimos:

2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]-benzonitrile hydrochloride (1:1), NPS-2143 hydrochloride, SB-262470-A hydrochloride

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Fórmula empírica (notación de Hill):

C₂₄H₂₅ClN₂O₂ · HCl

Número CAS:

324523-20-8

Peso molecular:

445.38

UNSPSC Code:

12352200

PubChem Substance ID:

329825364

NACRES:

NA.77

MDL number:

MFCD16038896

Assay:

≥98% (HPLC)

Form:

powder

Storage condition:

desiccated

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Propiedades

Nombre del producto

NPS2143 hydrochloride, ≥98% (HPLC)

Quality Segment

100

assay

≥98% (HPLC)

form

powder

optical activity

[α]20/D +20 to +24°, c = 1.0 in methanol

storage condition

desiccated

color

white to beige

solubility

DMSO: >10 mg/mL

storage temp.

2-8°C

SMILES string

Cl.CC(C)(Cc1ccc2ccccc2c1)NC[C@@H](O)COc3cccc(Cl)c3C#N

InChI

1S/C24H25ClN2O2.ClH/c1-24(2,13-17-10-11-18-6-3-4-7-19(18)12-17)27-15-20(28)16-29-23-9-5-8-22(25)21(23)14-26;/h3-12,20,27-28H,13,15-16H2,1-2H3;1H/t20-;/m1./s1

InChI key

ZEBNDUQLNGYBNL-VEIFNGETSA-N

Descripción

Application

NPS2143 hydrochloride has been used to study the function of calcium-sensing receptor :

In the regulation of intestinal calcium transport.
In the regulation of local negative feedback of intestinal calcium absorption.
In sensorimotor decision making during development.

Biochem/physiol Actions

NPS2143 is a selective calcium-sensing receptor (CaR) antagonist.

NPS2143 is a selective calcium-sensing receptor (CaR) antagonist. The compound blocks increases in cytoplasmic calcium concentrations with an IC₅₀ of 43 nM, and stimulates parathyroid hormone (PTH) secretion from bovine parathyroid cells over a wide range of extracellular calcuim concentrations.

NPS2143 is a phenylalkylamine calcilytic compound, and might be useful in treating autosomal dominant hypocalcemia. It serves as a blocking agent for hERG (human ether-a-go-go-related gene ) channel, CYP2D6 (cytochrome P450 2D6 ) and monoamine transporters.

pictograms

GHS07,GHS09

signalword

Warning

hcodes

H302 + H312 + H332,H410

pcodes

P261 - P273 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c