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SML1314

SAG dihydrochloride

Name: SAG dihydrochloride
Brand: SIGMA

≥98% (HPLC), lyophilized solid, smoothened (Smo) agonist

Sinónimos:

3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]-benzo[b]thiophene-2-carboxamide dihydrochloride, Smoothened Agonist

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Fórmula empírica (notación de Hill):

C₂₈H₂₈ClN₃OS · 2HCl

Número CAS:

912545-86-9

Peso molecular:

562.98

UNSPSC Code:

51111800

PubChem Substance ID:

329825779

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

lyophilized solid

Storage condition:

desiccated

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Propiedades

Nombre del producto

SAG dihydrochloride, ≥98% (HPLC)

Quality Segment

100

assay

≥98% (HPLC)

form

lyophilized solid

storage condition

desiccated

color

white to beige

solubility

H₂O: 20 mg/mL, clear

storage temp.

−20°C

SMILES string

O=C(C1=C(Cl)C2=C(C=CC=C2)S1)N([C@@]3([H])CC[C@@](NC)([H])CC3)CC4=CC(C5=CC=NC=C5)=CC=C4

InChI

1S/C28H28ClN3OS/c1-30-22-9-11-23(12-10-22)32(28(33)27-26(29)24-7-2-3-8-25(24)34-27)18-19-5-4-6-21(17-19)20-13-15-31-16-14-20/h2-8,13-17,22-23,30H,9-12,18H2,1H3/t22-,23-

InChI key

VFSUUTYAEQOIMW-YHBQERECSA-N

Descripción

Application

Smoothened agonist (SAG) dihydrochloride has been used as a sonic hedgehog (SHH) pathway agonist:

to study its effects on mouse hippocampal cells
to determine its effects on the mitochondrial network in zebrafish embryo
to study its effects on murine embryonic fibroblasts

Biochem/physiol Actions

SAG is a potent and cell-permeable smoothened (Smo) agonist that activates Hedgehog pathway and counteracts Cyclopamine inhibition of Smo.

SAG is a potent and cell-permeable smoothened (Smo) agonist.

pictograms

GHS06

signalword

Danger

hcodes

H301,H413

pcodes

P264 - P270 - P273 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Chronic 4

Clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c