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Merck

48554

N-Nitrosodi-n-propylamine

analytical standard

Sinónimos:

NDPA

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Fórmula empírica (notación de Hill):
C6H14N2O
Número CAS:
621-64-7
Peso molecular:
130.19
UNSPSC Code:
12352200
PubChem Substance ID:
24872091
EC Number:
210-698-0
MDL number:
MFCD00013891
NACRES:
NA.24

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Nombre del producto

N-Nitrosodi-n-propylamine, analytical standard

InChI key

YLKFDHTUAUWZPQ-UHFFFAOYSA-N

InChI

1S/C6H14N2O/c1-3-5-8(7-9)6-4-2/h3-6H2,1-2H3

SMILES string

CCCN(CCC)N=O

grade

analytical standard

CofA

current certificate can be downloaded

packaging

ampule of 100 mg

manufacturer/tradename

Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

cleaning products
cosmetics
environmental
food and beverages
personal care

format

neat

storage temp.

2-30°C

Quality Level

100

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Analysis Note

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Application

N-Nitrosodi-n-propylamine may be used as an analytical reference standard for the determination of volatile nitrosamines in meat samples using gas chromatography coupled with flame ionization detector (GC-FID) technique.

General description

Nitrosamines are chemical compounds that can form during drug manufacturing and may pose health risks, including carcinogenicity.
N-Nitrosodi-n-propylamine solution is commonly employed as a reference compound in analytical chemistry. It is utilized in chromatographic and spectrometric techniques for the detection and quantification of nitrosamines in chemical, pharmaceutical, and environmental matrices.

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - Carc. 1B

Clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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Certificados de análisis (COA)

Lot/Batch Number
LRAD6012
LRAC6182
LRAD2497
LRAC9445
LC26917V

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J G Farrelly et al.
Carcinogenesis, 5(8), 1015-1019 (1984-08-01)
Nitrosodiallylamine has been reported to be non-carcinogenic in rats while nitrosodipropylamine and nitrosodiethanolamine are liver carcinogens. That nitrosodipropylamine is metabolized at the alpha-position by liver microsomes from Fischer-344 rats supports the widely held contention that such metabolism is responsible for
K E Appel et al.
IARC scientific publications, (57)(57), 443-451 (1984-01-01)
Nitrite was formed on incubation of N-nitrosamines with both microsomal systems and a reconstituted system consisting of cytochrome P-450 and NADPH P-450 reductase from pig liver. Nitrite was not obtained when the nitrosamines were incubated with NADPH P-450 reductase alone
A Martelli et al.
Cancer research, 48(15), 4144-4152 (1988-08-01)
Ten carcinogenic N-nitroso compounds were assayed for DNA-damaging activity in primary cultures of human and rat hepatocytes. DNA fragmentation was measured by the alkaline elution technique, and unscheduled DNA synthesis by quantitative autoradiography. Positive dose-related responses in the range of
Development and validation of GC-FID method for the determination of volatile N-nitrosamines in meat
Al-Kaseem M, et al.
International Journal of Pharmaceutical Sciences Review and Research, 25, 59-64 (2014)
D Wotherspoon et al.
Journal - Association of Official Analytical Chemists, 71(2), 333-336 (1988-03-01)
A quick method for determining N-nitrosodipropylamine (NDPA) levels in trifluralin emulsifiable concentrate formulations is described. At least 18 samples can be analyzed at one time in a minimum of fumehood space, with up to 90% savings on solvents and materials.
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