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Merck

48554

N-Nitrosodi-n-propylamine

analytical standard

Sinónimos:

NDPA

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Fórmula empírica (notación de Hill):
C6H14N2O
Número CAS:
621-64-7
Peso molecular:
130.19
UNSPSC Code:
12352200
PubChem Substance ID:
24872091
EC Number:
210-698-0
MDL number:
MFCD00013891
NACRES:
NA.24

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grade

analytical standard

Quality Level

100

CofA

current certificate can be downloaded

packaging

ampule of 100 mg

manufacturer/tradename

Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

cleaning products
cosmetics
environmental
food and beverages
personal care

format

neat

storage temp.

2-30°C

SMILES string

CCCN(CCC)N=O

InChI

1S/C6H14N2O/c1-3-5-8(7-9)6-4-2/h3-6H2,1-2H3

InChI key

YLKFDHTUAUWZPQ-UHFFFAOYSA-N

Categorías relacionadas

General description

Nitrosamines are chemical compounds that can form during drug manufacturing and may pose health risks, including carcinogenicity.
N-Nitrosodi-n-propylamine solution is commonly employed as a reference compound in analytical chemistry. It is utilized in chromatographic and spectrometric techniques for the detection and quantification of nitrosamines in chemical, pharmaceutical, and environmental matrices.

Application

N-Nitrosodi-n-propylamine may be used as an analytical reference standard for the determination of volatile nitrosamines in meat samples using gas chromatography coupled with flame ionization detector (GC-FID) technique.

Analysis Note

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - Carc. 1B

Clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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Certificados de análisis (COA)

Lot/Batch Number
LRAE0600
LRAD2497
LRAC9445
LRAD6012
LRAC6182

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Development and validation of GC-FID method for the determination of volatile N-nitrosamines in meat
Al-Kaseem M, et al.
International Journal of Pharmaceutical Sciences Review and Research, 25, 59-64 (2014)
A new method for quantifying N-nitrosamines in wastewater samples by gas chromatography?triple quadrupole mass spectrometry.
Yoon S, et al.
Talanta, 97, 256-261 (2012)
S M Billedeau et al.
Journal - Association of Official Analytical Chemists, 67(3), 557-562 (1984-05-01)
A rapid and sensitive procedure is described for determining 4 N-nitrosodialkylamines (dimethyl, diethyl, dipropyl, and dibutyl) and the N-nitroso analogs of piperidine, pyrrolidine, and morpholine in animal feed. The volatile N-nitrosamines were isolated by using a modified high temperature purge
D Wotherspoon et al.
Journal - Association of Official Analytical Chemists, 71(2), 333-336 (1988-03-01)
A quick method for determining N-nitrosodipropylamine (NDPA) levels in trifluralin emulsifiable concentrate formulations is described. At least 18 samples can be analyzed at one time in a minimum of fumehood space, with up to 90% savings on solvents and materials.
J G Farrelly et al.
Carcinogenesis, 5(8), 1015-1019 (1984-08-01)
Nitrosodiallylamine has been reported to be non-carcinogenic in rats while nitrosodipropylamine and nitrosodiethanolamine are liver carcinogens. That nitrosodipropylamine is metabolized at the alpha-position by liver microsomes from Fischer-344 rats supports the widely held contention that such metabolism is responsible for
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