ABD12-25UG | Anti-Aldehyde dehydrogenase 1 (ALDH1A1) (rabbit polyclonal)

ABD12-25UG
25 μg  
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      Description
      Catalogue NumberABD12-25UG
      DescriptionAnti-Aldehyde dehydrogenase 1 (ALDH1A1) (rabbit polyclonal)
      Alternate Names
      • aldehyde dehydrogenase 1 family, member A1
      • ALDH class 1
      • Aldehyde dehydrogenase, cytosolic
      • retinaldehyde dehydrogenase 1
      • Aldehyde dehydrogenase family 1 member A1
      • retinal dehydrogenase 1
      • acetaldehyde dehydrogenase 1
      • aldehyde dehydrogenase 1, soluble
      • aldehyde dehydrogenase, liver cytosolic
      Background InformationAldehyde dehydrogenase 1A1 (ALDH1A1) is also known as retinal dehydrogenase 1. It is thought to be a main converter of retinol to retinoic acid, which is very important in cell to cell signaling. ALDH1A1 may also be involved in inhibiting invasion in pancreatic cancer cells. More specifically, ALDH1A1 may regulate hematopoietic stem cell differentiation by disrupting the retinoid signaling.
      References
      Product Information
      FormatAffinity Purified
      Control
      • HepG2 cell lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationThis Anti-Aldehyde dehydrogenase 1 (ALDH1A1) Antibody is validated for use in WB for the detection of Aldehyde dehydrogenase 1 (ALDH1A1).
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human Aldehyde dehydrogenase 1.
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      Species Reactivity
      • Human
      Species Reactivity NoteDemonstrated to react with human.
      Other homologies: rat and mouse (91% sequence homology).
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis protein belongs to the aldehyde dehydrogenases family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have only the cytosolic isozyme, missing the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of the mitochondrial isozyme. This gene encodes a cytosolic isoform, which has a high affinity for aldehydes. [provided by RefSeq].
      Gene Symbol
      • RALDH1
      • ALDH11
      • ALHDII
      • ALDC
      • ALDH-E1
      • ALDH1
      • PUMB1
      • RalDH1
      • RALDH 1
      • ALDH1A1
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Binds free retinal and cellular retinol-binding protein-bound retinal. Can convert/oxidize retinaldehyde to retinoic acid (By similarity).

      CATALYTIC ACTIVITY: Retinal + NAD+ + H2O = retinoate + NADH.

      PATHWAY: Cofactor metabolism; retinol metabolism.

      SUBUNIT STRUCTURE: Homotetramer.

      SUBCELLULAR LOCATION: Cytoplasm.

      SEQUENCE SIMILARITIES: Belongs to the aldehyde dehydrogenase family.
      Molecular Weight~54 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in HepG2 cell lysate.

      Western Blot Analysis: 0.05 µg/mL of this antibody detected Aldehyde dehydrogenase 1 on 10 µg of HepG2 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size25 μg
      Transport Information
      Supplemental Information
      Specifications

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