MABT861 | Anti-CDCP1 (CD318) Antibody, clone 9A2

MABT861
100 μg  
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      概要

      Replacement Information

      主要スペック表

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, H FC M Purified Monoclonal Antibody
      Description
      Catalogue NumberMABT861
      DescriptionAnti-CDCP1 (CD318) Antibody, clone 9A2
      Alternate Names
      • CUB domain-containing protein 1
      • Membrane glycoprotein gp140
      • Subtractive immunization M plus HEp3-associated 135 kDa protein
      • SIMA135
      • Transmembrane and associated with Src kinases
      • CD318
      Background InformationCUB domain-containing protein 1 (UniProt: Q9H5V8; also known as Membrane glycoprotein gp140, Subtractive immunization M plus HEp3-associated 135 kDa protein, SIMA135, Transmembrane and associated with Src kinases, CD318) is encoded by the CDCP1 (also known as TRASK) gene (Gene ID: 64866) in human. CUB domain-containing protein 1 is a single-pass membrane protein that is synthesized with a 29 amino acid signal peptide, which is subsequently cleaved to generate the mature form. A soluble form of CUB domain-containing protein 1 has also been reported that is produced by proteolytic cleavage at the cell surface. CUB domain-containing protein 1 is highly expressed in mitotic cells with low expression during interphase. It is detected at highest levels in skeletal muscle and colon. Lower expression is reported in kidney, small intestine, placenta, and lung. It is also reported in cells with phenotypes reminiscent of mesenchymal stem cells and neural stem cells. CUB domain-containing protein 1 levels are up-regulated in a number of human tumor cell lines and in colorectal cancer, breast carcinoma and lung cancer. It is reported to be involved in cell adhesion and cell matrix association and may play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal antibody IgG2b in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-CDCP1 (CD318), clone 9A2, Cat. No. MABT861, is a mouse monoclonal that detects CUB domain-containing protein 1 and has been tested for use in Flow Cytometry.
      Key Applications
      • Flow Cytometry
      Application NotesFlow Cytometry Analysis: 1 µg from a representative lot detected CDCP1 CD318 in MDA-MB231 cells.


      Biological Information
      ImmunogenHis-tagged recombinant fragment corresponding to 638 amino acids from the internal region of human CUB domain-containing protein 1.
      Epitopeextracellular domain
      Clone9A2
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone 9A2 detects CUB domain-containing protein 1 in human and murine cells. It targets an epitope within the extracellular domain.
      IsotypeIgG2bκ
      Species Reactivity
      • Mouse
      • Human
      Species Reactivity NoteHuman, Mouse.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • CDCP1
      • TRASK
      Purification MethodProtein G purified
      UniProt Number
      Molecular Weight92.93 kDa calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Flow Cytometry in DLD-1 cells.

      Flow Cytometry Analysis: 1 µg of this antibody detected CDCP1 CD318 in one million DLD-1 cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications