MABT1504-100UG | Anti-Calponin Antibody, clone CALP

新着MABT1504-100UG
100 μg  
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      概要

      Replacement Information

      主要スペック表

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      B, H, Porcine WB, IH(P) M Purified Monoclonal Antibody
      Description
      Catalogue NumberMABT1504-100UG
      DescriptionAnti-Calponin Antibody, clone CALP
      Alternate Names
      • Basic calponin
      • Calponin H1 smooth muscle
      Background InformationCalponin-1 (UniProt: P51911; also known as Basic calponin, Calponin H1 smooth muscle) is encoded by the CNN1 gene (Gene ID:1264) in human. Calponin is an actin filament-associated regulatory protein that is expressed in smooth muscle and non-muscle cells of vertebrates. Three isoforms of Calponin have been reported that inhibit actin-activated myosin ATPase activity and stabilize the actin cytoskeleton. Calponin 1 is specifically expressed in smooth muscle cells is involved in fine-tuning of smooth muscle contractility. Calponin-2 is found in multiple cell types, including developing smooth muscles and Calponin-3 is found in the neurons, astrocytes and glial cells. Calponin-1 can bind to actin, calmodulin, troponin C, and tropomyosin. Calponin-1 (and other calponins) has a calponin homology (CH) domain at its N-terminal (aa 28-131) that can function either as a part of actin-binding site or serve as a regulatory structure for actin-binding activity. It also has three calponin-like domains (aa 164-189; 204-229; and 243-268) next to the C-terminal region that are conserved in all calponins. The C-terminal segment varies among different calponins and has differentiated effects on weakening the binding of calponin to F-actin. Deletion of the C-terminal tail segment is shown to enhance the actin-binding and bundling activities of calponins. (Ref.: Liu, R., and Jin, J-P (2016). Gene 585(1); 143-153).
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-Calponin, clone CALP , Cat. No. MABT1504, is a mouse monoclonal antibody that detects Calponin-1 and has been tested for use in Immunohistochemistry (Paraffin) and Western Blotting.
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry (Paraffin) Analysis: A 1:250 dilution from a representative lot detected Calponin in human uterus and human prostate tissue sections.
      Biological Information
      ImmunogenCrude human uterine muscle extract.
      CloneCALP or N3/16
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone CALP specifically detects human Calponin-1.
      IsotypeIgG1κ
      Species Reactivity
      • Bovine
      • Human
      • Porcine
      Species Reactivity NoteHuman, Bovine, Porcine.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • CNN1
      Purification MethodProtein G purified
      UniProt Number
      Molecular Weight~36 kDa observed; 33.17 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human aortic smooth muscle tissue lysate.

      Western Blotting Analysis: 1 µg/mL of this antibody detected Calponin in human aortic smooth muscle tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications