MABT838-100UG | Anti-Myosin 7 (MYH7) Antibody, clone BA-D5

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100 μg  
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      概要

      Replacement Information
      Description
      Catalogue NumberMABT838-100UG
      DescriptionAnti-Myosin 7 (MYH7) Antibody, clone BA-D5
      Alternate Names
      • Myosin heavy chain 7
      • Myosin heavy chain slow isoform
      • MyHC-slow
      • Myosin heavy chain
      • Cardiac muscle beta isoform
      • MyHC-beta)
      Background InformationMyosin-7 (UniProt: Q9BE39; also known as Myosin heavy chain 7, Myosin heavy chain slow isoform, MyHC-slow, Myosin heavy chain, cardiac muscle beta isoform, MyHC-beta) is encoded by the MYH7 gene (Gene ID: 282714) in bovine species. Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Myosins form regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. Myosin-7 is a component of thick filaments of the myofibrils. It contains actin- and ATP-binding sites in its conserved catalytic head domain. Its actin binding region is localized to amino acids 655-677 and 757-771 and the ATP-binding region is localized to amino acids 178-185. Myosin-7 has an N-terminal SH3-like domain (aa 32-81), a myosin motor domain (aa 85-778), and an IQ domain (aa 781-810). Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Limited proteolysis of myosin heavy chain produces one light meromyosin (LMM) and one heavy meromyosin (HMM). HMM can be further cleaved into two globular sub fragments (S1) and 1 rod-shaped sub fragment (S2).
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal antibody IgG2b in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-Myosin 7 (MYH7), clone BA-D5, Cat. No. MABT838, is a mouse monoclonal antibody that detects Myosin-7 and has been tested for use in Immunofluorescence, Immunohistochemistry, and Western Blotting.
      Key Applications
      • Immunofluorescence
      • Immunohistochemistry
      • Western Blotting
      Application NotesImmunohistochemistry Analysis: A representative lot detected Myosin 7 (MYH7) in Immunohistochemistry applications (Goh, Q., et. al. (2017). Elife. 6. pii: e20007).

      Western Blotting Analysis: A representative lot detected Myosin 7 (MYH7) in Western Blotting applications (De Jong, A., et. al. (2017). PLoS One. 12(3):e0174043; Gan, Z., et. al. (2013). J Clin Invest. 123(6):2564-75).

      Immunofluorescence Analysis: A representative lot detected Myosin 7 (MYH7) in Immunofluorescence applications (Gan, Z., et. al. (2013). J Clin Invest. 123(6):2564-75; Pannerec, A., et. al. (2016). Aging (Albany NY). 8(4):712-29).
      Biological Information
      ImmunogenPurified myosin from bovine atrium.
      CloneBA-D5
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone BA-D5 detects Myosin-7 in multiple mammalian species. It detects both alpha- and beta-slow myosin heavy chain.
      IsotypeIgG2bκ
      Species Reactivity
      • Human
      • Mouse
      Species Reactivity NoteMouse, Human.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Myh7
      Purification MethodProtein G purified
      UniProt Number
      Molecular Weight~220 kDa observed; 223.23 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in mouse soleus muscle tissue lysate.

      Western Blotting Analysis: 4 µg/mL of this antibody detected Myosin 7 (MYH7) in mouse soleus muscle tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications

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